Introduction Verquvo is the brand name of vericiguat, an oral soluble guanylate cyclase stimulator used in selected adults with symptomatic chronic heart failure. It is mainly used in patients with heart failure and ejection fraction less than 45% who have recently had worsening heart failure requiring hospitalization or outpatient intravenous diuretic therapy. Its clinical role … Read more
Introduction Vasodilators are a diverse group of drugs that produce relaxation of vascular smooth muscle, resulting in widening of blood vessels and improved blood flow. They are commonly used in the management of hypertension, heart failure, angina pectoris, hypertensive emergencies, pulmonary hypertension, and various cardiovascular disorders. The therapeutic effects of vasodilators arise from their ability … Read more
Introduction ARNI (Angiotensin Receptor–Neprilysin Inhibitor) represents a major advancement in the treatment of heart failure with reduced ejection fraction (HFrEF). The most widely used ARNI is the fixed-dose combination Sacubitril/Valsartan, marketed as Entresto. Mechanism of Action of ARNI involves dual inhibition of the renin–angiotensin–aldosterone system (RAAS) and the neprilysin (neutral endopeptidase) pathway. This unique mechanism … Read more
