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Mechanism of Action of Fluconazole

Mechanism of Action of Fluconazole

Introduction Fluconazole is a triazole antifungal agent widely used in the treatment and prophylaxis of systemic and superficial fungal infections. It is especially effective against Candida species and Cryptococcus neoformans. Fluconazole is high-yield for pharmacology and infectious disease examinations due to its selective inhibition of fungal sterol synthesis, excellent oral bioavailability, CNS penetration, and characteristic … Read more

Mechanism of Action of Azole Antifungal

MOA of Azole Antifungal Drugs

Introduction Azoles are a major class of antifungal drugs widely used for the treatment of systemic and superficial fungal infections. They include imidazoles (e.g., ketoconazole, clotrimazole, miconazole) and triazoles (e.g., fluconazole, itraconazole, voriconazole, posaconazole). Mechanism of Action of Azole Antifungal Drugs centers on the inhibition of fungal ergosterol synthesis, an essential component of the fungal … Read more

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