Introduction Biguanides are a class of oral antihyperglycemic drugs, with metformin being the only widely used agent today. Metformin is the first-line therapy for type 2 diabetes mellitus due to its excellent safety profile, weight-neutral effect, and strong efficacy in lowering blood glucose without causing hypoglycemia. Mechanism of Action of Biguanides centers on decreasing hepatic … Read more
1.Identification SummaryFirst-line oral antihyperglycemic (biguanide) used in type 2 diabetes mellitus; lowers hepatic glucose output, improves insulin sensitivity, and has minimal risk of hypoglycemia when used alone. Brand NamesGlucophage, Riomet, Fortamet, Glumetza (regional availability varies) NameMetformin BackgroundA synthetic dimethylbiguanide introduced clinically in the mid-20th century; retained on essential-medicine lists worldwide due to efficacy, safety profile, … Read more
