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Mechanism of Action of Deucravacitinib

Mechanism of Action of Deucravacitinib

Introduction Deucravacitinib is an oral immunomodulatory drug marketed under the brand name Sotyktu. Pharmacologically, deucravacitinib is a selective tyrosine kinase 2 inhibitor, commonly called a TYK2 inhibitor. Psoriasis and psoriatic arthritis are immune-mediated inflammatory diseases involving abnormal cytokine signaling, T-cell activation, keratinocyte inflammation, synovial inflammation, enthesitis, and systemic immune dysregulation. Important inflammatory pathways include interleukin-23, … Read more

Mechanism of Action of Upadacitinib

Upadacitinib Mechanism of Action

Introduction Upadacitinib is an oral Janus kinase inhibitor used in several immune-mediated inflammatory diseases. It is marketed under the brand name Rinvoq and is commonly classified as a selective JAK1 inhibitor, although it can affect other JAK enzymes at higher concentrations. Upadacitinib is used in conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic … Read more

Mechanism of Action of Ruxolitinib

Mechanism of Action of Ruxolitinib

Introduction Ruxolitinib is an oral Janus kinase inhibitor used mainly in hematological and immune-mediated disorders. It is best known by the brand name Jakafi for systemic use, and it selectively inhibits Janus kinase 1 and Janus kinase 2, commonly called JAK1 and JAK2. Ruxolitinib is important in pharmacology because JAK enzymes are central mediators of … Read more

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