Mechanism of Action of Hydrochlorothiazide (HCTZ)
Introduction Hydrochlorothiazide (HCTZ) is a thiazide diuretic widely used in the treatment of hypertension, edema, and certain kidney disorders. It acts primarily on the distal convoluted tubule of the nephron to promote sodium and water excretion. By reducing extracellular fluid volume and decreasing peripheral vascular resistance, hydrochlorothiazide effectively lowers blood pressure. Thiazide diuretics are among … Read more