Mechanism of Action of Sitagliptin
Introduction Sitagliptin is an oral dipeptidyl peptidase‑4 (DPP‑4) inhibitor used to manage type 2 diabetes mellitus (T2DM). It improves glycemic control by enhancing incretin hormone activity, leading to increased insulin secretion and decreased glucagon release in a glucose-dependent manner. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral Bioavailability ~87% Protein Binding ~38% Metabolism … Read more