nephrotoxicity

Introduction Cyclosporine is a calcineurin inhibitor used primarily to prevent organ transplant rejection and to treat select autoimmune disorders. It binds to cyclophilin, forming a complex that inhibits calcineurin, thereby blocking T‑cell activation and interleukin‑2 (IL‑2) production. This selective immunosuppression reduces T‑lymphocyte–mediated damage. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Bioavailability ~30% (range 10–90%) … Read more