Mechanism of Action of Sulfasalazine
Introduction Sulfasalazine is a disease-modifying antirheumatic drug (DMARD) and anti-inflammatory agent used primarily in inflammatory bowel disease (IBD), rheumatoid arthritis, and other autoimmune disorders. It is a prodrug consisting of sulfapyridine linked to 5-aminosalicylic acid (5-ASA, mesalamine) by an azo bond. After reaching the colon, bacterial enzymes cleave the bond, releasing the active components that … Read more