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Mechanism of Action of Mirtazapine

MOA of Mirtazapine

Introduction Mirtazapine is an atypical antidepressant classified as a noradrenergic and specific serotonergic antidepressant (NaSSA). It is commonly used in major depressive disorder, particularly in patients with insomnia, weight loss, or anxiety. Unlike SSRIs and TCAs, mirtazapine enhances neurotransmitter release by blocking inhibitory receptors rather than inhibiting reuptake. Mechanism of Action (Step-wise) A key exam … Read more

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