Mechanism of Action of Metolazone
Introduction Metolazone is a thiazide-like diuretic commonly used in the management of hypertension and edema, particularly in patients with heart failure or chronic kidney disease. It is especially useful when combined with loop diuretics in resistant edema. Metolazone acts primarily on the distal convoluted tubule of the nephron to promote sodium and water excretion. Mechanism … Read more