Mechanism of Action of Hydroxyurea
Introduction Hydroxyurea is an antineoplastic and hematologic agent used in the treatment of several conditions including chronic myelogenous leukemia (CML), sickle cell anemia, and certain solid tumors. Its therapeutic effectiveness is derived from its ability to inhibit DNA synthesis and modulate erythropoiesis. Hydroxyurea’s distinct dual mechanism—cytotoxicity in cancer and fetal hemoglobin induction in sickle cell … Read more