local anesthetics - Pharmacy Freak

Mechanism of Action of Lidocaine

April 10, 2026March 26, 2026 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Lidocaine is a widely used local anesthetic and class IB antiarrhythmic drug. It is commonly used for local and regional anesthesia as well as in the management of ventricular arrhythmias. Lidocaine works by blocking nerve conduction and stabilizing cardiac membranes. Mechanism of Action (Step-wise) Pharmacokinetics Clinical Uses Adverse Effects Comparative Analysis Feature Lidocaine Bupivacaine … Read more

Mechanism of Action of Bupivacaine

April 10, 2026November 26, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Bupivacaine is a long-acting amide-type local anesthetic widely used for regional anesthesia, epidural anesthesia, nerve blocks, infiltration anesthesia, and obstetric analgesia. It is known for its high potency, long duration of action, and strong sensory blockade. Because of its strong affinity for cardiac sodium channels, it carries a higher risk of cardiotoxicity compared to … Read more