Amiloride

Introduction Amiloride is a potassium-sparing diuretic that acts on the distal nephron of the kidney to promote sodium excretion while conserving potassium. Mechanism of Action of Amiloride involves direct inhibition of epithelial sodium channels (ENaC) in the late distal tubule and collecting duct, leading to decreased sodium reabsorption and reduced potassium excretion. Unlike aldosterone antagonists … Read more