Pharmacy Freak Editorial Team

Introduction: De novo drug design and fragment-based approaches MCQs With Answer is a focused quiz set tailored for M.Pharm students studying MPC 203T Computer Aided Drug Design. This collection emphasizes conceptual depth and practical application, covering structure-based and ligand-based de novo strategies, fragment screening techniques, fragment growing/linking/merging, scoring and synthetic feasibility, and experimental validation methods … Read more

Introduction: This quiz set on ADMET prediction and in silico property analysis is designed for M.Pharm students preparing for MPC 203T Computer Aided Drug Design. It focuses on practical and theoretical aspects of predicting Absorption, Distribution, Metabolism, Excretion and Toxicity using computational tools. Questions emphasize molecular descriptors, rule-based filters, machine learning approaches, common software platforms, … Read more

Molecular docking: rigid, flexible and extra-precision docking MCQs With Answer Introduction: Molecular docking is a cornerstone technique in computer-aided drug design that predicts how small molecules bind to target macromolecules. This quiz set focuses on distinctions between rigid, flexible, and extra-precision (XP) docking approaches, covering sampling algorithms, scoring functions, receptor and ligand flexibility, and practical … Read more

Energy minimization and conformational analysis are core concepts in computer-aided drug design that allow M.Pharm students to understand how small molecules adopt low-energy shapes and how those shapes influence binding and activity. This blog provides concise, exam-focused multiple-choice questions that cover force fields, potential energy surfaces, minimization algorithms, torsional sampling, solvent models, and conformational search … Read more

Molecular mechanics and quantum mechanics in drug design MCQs With Answer This collection of multiple-choice questions is tailored for M.Pharm students studying MPC 203T: Computer Aided Drug Design. The questions focus on the theoretical foundations and practical applications of molecular mechanics (MM) and quantum mechanics (QM) methods used in modern drug discovery. Topics include force … Read more

Introduction: This quiz collection focuses on statistical methods in QSAR (Quantitative Structure–Activity Relationship) and validation metrics tailored for M.Pharm students studying Computer Aided Drug Design. It covers core concepts such as regression techniques, descriptor selection, multicollinearity, cross-validation strategies, and external validation metrics used to judge model robustness and predictivity. Emphasis is placed on practical validation … Read more

Introduction 3D-QSAR: CoMFA, CoMSIA and contour map analysis MCQs With Answer is a focused quiz resource designed for M.Pharm students studying MPC 203T – COMPUTER AIDED DRUG DESIGN. This set consolidates core concepts of 3D-QSAR, comparing CoMFA and CoMSIA methodologies, outlining practical modelling choices (alignment, grid, probe, charge methods), and emphasizing contour map interpretation for … Read more

Introduction Hansch analysis, Free–Wilson and 2D QSAR methods MCQs With Answer This quiz set is designed for M.Pharm students studying MPC 203T (Computer Aided Drug Design). It focuses on Hansch analysis, the Free–Wilson approach and modern 2D QSAR — key quantitative strategies for relating chemical structure to biological activity. Questions emphasize conceptual understanding of substituent … Read more

QSAR basics: physicochemical parameters and Hammett/Taft analysis provides M.Pharm students with a focused review of key quantitative structure–activity relationship concepts. This blog covers how molecular descriptors — such as lipophilicity (logP/π), electronic substituent constants (Hammett σ), Taft steric (Es) and polar (σ*) terms, pKa, hydrogen-bonding, and polar surface area — influence biological activity. Emphasis is … Read more