Introduction Chloroquine is a 4-aminoquinoline antimalarial drug historically used for the treatment and prophylaxis of Plasmodium falciparum, P. vivax, P. malariae, and P. ovale infections. Although resistance limits its use in many regions, chloroquine remains essential for sensitive strains and for autoimmune diseases such as rheumatoid arthritis and lupus. The Mechanism of Action of Chloroquine … Read more
Introduction Chlorhexidine is a broad-spectrum antiseptic and disinfectant widely used in clinical practice for skin preparation, oral hygiene, wound cleansing, surgical scrubs, and catheter care. It is highly effective against gram-positive and gram-negative bacteria, yeasts, and some viruses. The Mechanism of Action of Chlorhexidine is based on disruption of microbial cell membranes, leading to leakage … Read more
Introduction Cetirizine is a second-generation antihistamine widely used for the management of allergic rhinitis, urticaria, and other allergic disorders. It is favored for its minimal sedative effects, long duration of action, and excellent safety profile. The Mechanism of Action of Cetirizine involves selective antagonism of peripheral H1 histamine receptors, reducing allergic symptoms such as itching, … Read more
Introduction Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor used widely for pain, inflammation, and osteoarthritis/rheumatoid arthritis management. Unlike nonselective NSAIDs, celecoxib spares COX-1, reducing the risks of gastric irritation and gastrointestinal bleeding while providing potent anti-inflammatory and analgesic effects. The Mechanism of Action of Celecoxib centers on selective inhibition of COX-2, leading to decreased synthesis … Read more
Introduction Carvedilol is a nonselective beta-blocker with additional alpha-1 blocking activity. It is widely used in heart failure, hypertension, ischemic heart disease, and for reducing mortality post-myocardial infarction. Unlike traditional beta-blockers, carvedilol provides combined beta-blockade, alpha-blockade, antioxidant properties, and anti-remodeling effects, making it a cornerstone therapy in chronic heart failure. The Mechanism of Action of … Read more
Introduction Carbonic anhydrase inhibitors (CAIs) are a class of diuretics and antiglaucoma drugs represented primarily by acetazolamide, dorzolamide, and brinzolamide. They reduce bicarbonate reabsorption in the kidney, decrease aqueous humor formation in the eye, and modulate cerebrospinal fluid (CSF) production. The Mechanism of Action of Carbonic Anhydrase Inhibitors centers on blocking the enzyme carbonic anhydrase … Read more
Introduction Carbimazole is a thiourea-derived antithyroid drug used primarily in the management of hyperthyroidism, especially Graves’ disease, toxic multinodular goiter, and thyroid storm (as adjunct therapy). After oral administration, carbimazole is rapidly converted to its active metabolite methimazole, which exerts the therapeutic effects. The Mechanism of Action of Carbimazole involves suppression of thyroid hormone synthesis … Read more
Introduction Carbapenems are a powerful class of beta-lactam antibiotics known for their broad-spectrum activity against gram-positive, gram-negative, and anaerobic bacteria. Common agents include imipenem, meropenem, ertapenem, and doripenem. They are often reserved for severe, hospital-acquired, or multidrug-resistant infections due to their potent activity and stability against most beta-lactamases. The Mechanism of Action of Carbapenems involves … Read more
Introduction Carbamazepine is a widely used antiepileptic and mood-stabilizing drug effective in the management of partial seizures, generalized tonic–clonic seizures, trigeminal neuralgia, and bipolar disorder. It stabilizes hyperexcitable neuronal membranes and reduces synaptic transmission. The Mechanism of Action of Carbamazepine is centered on use-dependent blockade of voltage-gated sodium channels, which reduces repetitive neuronal firing and … Read more
Introduction Captopril is a first-generation angiotensin-converting enzyme (ACE) inhibitor used in the management of hypertension, heart failure, diabetic nephropathy, and post-myocardial infarction ventricular remodeling. It was the first ACE inhibitor developed and remains clinically relevant, especially for acute blood pressure control due to its rapid onset. The Mechanism of Action of Captopril is based on … Read more
