Chemotherapy Nausea Treatment

Introduction Ondansetron is a highly selective 5‑hydroxytryptamine 3 (5‑HT₃) receptor antagonist used primarily as an antiemetic. It prevents nausea and vomiting triggered by chemotherapy, radiotherapy, surgery, and gastrointestinal irritants. It acts both peripherally in the gastrointestinal tract and centrally in the brainstem’s vomiting centers. Step‑by‑Step Mechanism of Action Pharmacokinetic Parameters Parameter Ondansetron Values Bioavailability ~60% … Read more