Mechanisms of drug-induced toxicity and idiosyncrasy MCQs With Answer
Introduction: Mechanisms of drug-induced toxicity and idiosyncrasy explore how drugs cause harmful effects through predictable dose-dependent pathways and unpredictable immune or genetic reactions. Key concepts include bioactivation to reactive metabolites, oxidative stress, mitochondrial dysfunction, cholestasis, transporter inhibition, hapten formation, the p-i concept, and pharmacogenomics (CYP polymorphisms, HLA alleles). Understanding organ-specific toxicities—hepatotoxicity, nephrotoxicity, cardiotoxicity—and clinical biomarkers … Read more
