Mechanism of Action of Tricyclic Antidepressants (TCAs)
Introduction Tricyclic antidepressants (TCAs) are a class of antidepressant drugs used in major depressive disorder, neuropathic pain, migraine prophylaxis, obsessive-compulsive disorder, and certain anxiety disorders. Common TCAs include amitriptyline, nortriptyline, imipramine, desipramine, and clomipramine. Their primary action is inhibition of serotonin and norepinephrine reuptake, leading to increased concentrations of these neurotransmitters in the central nervous … Read more