Sulfonamides – mechanism, resistance, and uses MCQs With Answer
Sulfonamides – mechanism, resistance, and uses Sulfonamides are PABA analogues that inhibit bacterial dihydropteroate synthase, blocking folate synthesis and impairing DNA production. In B.Pharm studies, focus on their mechanism (competitive inhibition of folate pathway), synergy with trimethoprim (sequential blockade), resistance mechanisms (mutated DHPS, increased PABA, plasmid-encoded sul genes, efflux), pharmacokinetics (absorption, acetylation, renal excretion), clinical … Read more
