Mechanism of Action of Sirolimus
Introduction Sirolimus, also known as rapamycin, is an immunosuppressant drug primarily used in organ transplantation and certain proliferative disorders. It inhibits T-cell activation and proliferation by blocking the mammalian target of rapamycin (mTOR) pathway. Unlike calcineurin inhibitors, sirolimus does not inhibit interleukin-2 production but instead blocks the cellular response to interleukin-2. Mechanism of Action (Step-wise) … Read more