Mechanism of Action of Lisinopril
Introduction Lisinopril is a long-acting angiotensin-converting enzyme (ACE) inhibitor used mainly in hypertension, heart failure, and selected patients after acute myocardial infarction. It acts primarily by suppressing the renin-angiotensin-aldosterone system (RAAS), thereby reducing vasoconstriction, aldosterone release, and maladaptive cardiovascular remodeling. Because ACE is also involved in bradykinin breakdown, lisinopril may increase bradykinin levels, which contributes … Read more