Mechanism of Action of Naltrexone
Introduction Naltrexone is a pure opioid antagonist primarily used to prevent relapse in opioid use disorder and reduce alcohol craving in alcohol dependence. It competitively blocks μ-opioid receptors and to a lesser extent κ and δ receptors, thereby diminishing the rewarding effects of opioids and alcohol without inducing any agonist activity. Step-by-Step Mechanism of Action … Read more