Mechanism of Action of Guanfacine
Introduction Guanfacine is a selective α₂A‑adrenergic receptor agonist used in treating ADHD and for managing hypertension. It enhances prefrontal cortex functioning by activating postsynaptic α₂A receptors, resulting in improved attention, impulse control, and reduced sympathetic tone. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Bioavailability ~70–80% (oral) Time to Peak (Tₘₐₓ) ~1–4 hours Half‑Life ~17 … Read more