V2 Receptor Antagonist

Introduction Semaglutide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1 RA) used for type 2 diabetes mellitus (T2DM) management and chronic weight management. It mimics endogenous GLP‑1 to improve glycemic control and promote weight loss through central appetite suppression and delayed gastric emptying. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Subcutaneous weekly injection Bioavailability … Read more

Introduction Tolvaptan is an oral vasopressin V₂ receptor antagonist, approved for treating hyponatremia due to SIADH, heart failure, or cirrhosis, and for slowing disease progression in autosomal dominant polycystic kidney disease (ADPKD). It increases free water excretion (aquaretic effect) without significant electrolyte loss. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral Bioavailability ~40% … Read more