prokinetic drug MOA - Pharmacy Freak

Mechanism of Action of Metoclopramide

April 10, 2026April 8, 2026 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Metoclopramide is a prokinetic and antiemetic drug commonly used in gastrointestinal disorders and nausea-related conditions. It enhances gastrointestinal motility and accelerates gastric emptying while also acting centrally to reduce nausea and vomiting. It is widely used in conditions such as gastroparesis, gastroesophageal reflux disease (GERD), and chemotherapy-induced nausea. Mechanism of Action (Step-wise) A key … Read more

Mechanism of Action of Domperidone

April 10, 2026January 6, 2026 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Domperidone is a peripherally selective dopamine D₂ receptor antagonist used primarily as a prokinetic and antiemetic agent. It enhances gastrointestinal motility and suppresses nausea and vomiting without significant central nervous system effects because of its poor penetration across the blood–brain barrier. Domperidone is a high-yield drug in pharmacology, gastroenterology, and clinical examinations due to … Read more