Mechanism of Action of Bosentan
Introduction Bosentan is an oral endothelin receptor antagonist (ERA) used primarily for the treatment of pulmonary arterial hypertension (PAH). Endothelin-1 (ET-1) is one of the most potent vasoconstrictors in the human body, and its overactivity plays a central role in the pathophysiology of PAH by causing vasoconstriction, vascular hypertrophy, smooth muscle proliferation, and fibrosis. Bosentan … Read more