Mechanism of Action of Entacapone
Introduction Entacapone is a catechol-O-methyltransferase (COMT) inhibitor used as an adjunct therapy in Parkinson’s disease, particularly in patients experiencing end-of-dose “wearing-off” phenomena with levodopa. It enhances and prolongs the effect of levodopa by reducing its peripheral metabolism. Entacapone is a high-yield drug in pharmacology and neurology examinations because of its enzyme inhibition–based mechanism and its … Read more