Urinary System Pharmacology | Pharmacology | GPAT Mock Test

1. Furosemide, a potent loop diuretic, exerts its primary action by inhibiting which of the following transporters in the thick ascending limb of the Loop of Henle?

2. Which class of diuretics is most likely to cause hyperkalemia as a side effect?

3. A patient with acute mountain sickness is prescribed a diuretic that acts on the proximal convoluted tubule. Which drug was likely prescribed?

4. Thiazide diuretics are known to have a “paradoxical” antidiuretic effect in which condition?

5. Spironolactone exerts its diuretic effect by acting as an antagonist at which receptor?

6. Which of the following diuretics is administered intravenously to reduce cerebral edema?

7. Desmopressin is a synthetic analogue of ADH with selectivity for which receptor, making it useful for treating central diabetes insipidus?

8. Which diuretic is known to cause ototoxicity, especially when administered rapidly via IV route in high doses?

9. The efficacy of thiazide diuretics diminishes significantly when the glomerular filtration rate (GFR) falls below:

10. Tolvaptan is an antidiuretic antagonist used for treating euvolemic hyponatremia. What is its mechanism of action?

11. Hyperuricemia, potentially leading to gout, is a common metabolic side effect associated with which two classes of diuretics?

12. Amiloride and Triamterene are potassium-sparing diuretics that act by:

13. Which of the following conditions is a contraindication for the use of mannitol?

14. The use of carbonic anhydrase inhibitors like acetazolamide leads to:

15. A patient with congestive heart failure and cirrhosis is prescribed a diuretic that can also block androgen receptors, causing gynecomastia. This drug is:

16. The primary site of action for thiazide diuretics is the:

17. Which of the following diuretics is a non-sulfonamide loop diuretic?

18. Impaired glucose tolerance and hyperglycemia are potential adverse effects of long-term therapy with which diuretic class?

19. The term “high-ceiling diuretic” refers to which class of drugs, indicating a steep dose-response curve?

20. What is the primary mechanism by which loop diuretics cause hypokalemia?

21. Eplerenone is considered a more selective alternative to spironolactone because it has a lower affinity for:

22. Which diuretic is most appropriate for a patient with acute pulmonary edema requiring rapid and potent diuresis?

23. Thiazide diuretics can cause hypercalcemia by:

24. What is the mechanism of action of osmotic diuretics like mannitol?

25. A patient on diuretic therapy develops hypochloremic metabolic alkalosis. This is a characteristic side effect of which class of diuretics?