Psoriasis MCQ Quiz | Papulosquamous Disorders

1. Which HLA allele is most strongly associated with early-onset psoriasis vulgaris?

2. Auspitz’s sign, characterized by pinpoint bleeding on removal of a psoriatic scale, is due to what histopathological feature?

3. The development of new psoriatic lesions at sites of skin trauma is known as:

4. A 7-year-old child presents with a sudden eruption of small, drop-like, scaly papules over the trunk and limbs following a sore throat. What is the most likely diagnosis?

5. Which of the following is a characteristic histopathological finding in psoriasis?

6. A patient with extensive psoriasis develops a widespread, fiery red rash covering most of their body surface area, accompanied by fever and malaise. This severe form is called:

7. Which cytokine pathway is a primary target for modern biologic therapies like Secukinumab and Ixekizumab in psoriasis?

8. Which of the following drugs is a known trigger or exacerbating factor for psoriasis?

9. Topical calcipotriol, a common treatment for plaque psoriasis, is an analogue of which vitamin?

10. In psoriatic arthritis (PsA), which pattern of joint involvement is most characteristic?

11. The mechanism of action of Methotrexate in treating severe psoriasis involves:

12. What are the collections of neutrophils within the parakeratotic stratum corneum seen in psoriasis histopathology called?

13. A patient with psoriasis presents with erythematous plaques in the axillae and groin that lack the typical silvery scale. This presentation is characteristic of:

14. Phototherapy with Narrowband UVB (NB-UVB) is an effective treatment for widespread psoriasis. What is the peak wavelength used?

15. Which of the following systemic retinoids is used in the treatment of severe psoriasis, particularly pustular and erythrodermic types?

16. The “oil drop” sign or “salmon patch” is a clinical finding associated with psoriasis affecting which part of the body?

17. In the pathogenesis of psoriasis, which cell type plays a central role in orchestrating the inflammatory cascade?

18. Pustular psoriasis of von Zumbusch is a severe, acute variant characterized by:

19. Which of the following is NOT a typical feature of a chronic plaque psoriasis lesion?

20. Patients with severe psoriasis are at an increased risk of developing which comorbidity?

21. PUVA therapy for psoriasis combines Psoralen with which type of ultraviolet light?

22. Suprapapillary thinning of the epidermis in psoriasis makes the underlying dermal capillaries more susceptible to trauma, leading to:

23. The classic psoriatic plaque is best described as:

24. Which TNF-alpha inhibitor is commonly used as a biologic agent for treating moderate-to-severe psoriasis and psoriatic arthritis?

25. Regular, rete ridge elongation, often described as “test tubes in a rack,” is a feature of which histological layer in psoriasis?