Pharmacology in Gynaecology (incl. Chemotherapy) MCQ Quiz | Basic Sciences

1. A 30-year-old woman is undergoing induction of labour. Which of the following best describes the mechanism of action of Oxytocin used for this purpose?

2. Clomiphene citrate is a first-line drug for ovulation induction in anovulatory infertility. What is its primary mechanism of action?

3. A 55-year-old woman on Tamoxifen therapy for breast cancer presents with post-menopausal bleeding. Which gynaecological malignancy is she at an increased risk of developing?

4. What is the standard first-line chemotherapy regimen for advanced epithelial ovarian cancer following cytoreductive surgery?

5. Which drug is used for the medical management of an unruptured ectopic pregnancy by inhibiting dihydrofolate reductase?

6. Nifedipine is used as a tocolytic agent to suppress preterm labour. Its mechanism of action involves:

7. Which prostaglandin analogue is commonly used for cervical ripening and induction of labour?

8. A 22-year-old female requests emergency contraception 48 hours after unprotected intercourse. Which of the following is the most effective oral option?

9. Letrozole is increasingly used for ovulation induction, especially in patients with PCOS. What is its mechanism of action?

10. Ergometrine is used to control postpartum haemorrhage. It is contraindicated in which of the following conditions?

11. The primary mechanism of combined oral contraceptives (COCs) in preventing pregnancy is:

12. A pregnant woman with severe pre-eclampsia is receiving magnesium sulfate infusion for seizure prophylaxis. She develops respiratory depression, loss of deep tendon reflexes, and oliguria. What is the specific antidote?

13. Cisplatin, a key drug in treating cervical cancer, has which of the following as its major dose-limiting toxicities?

14. Danazol is used for the treatment of endometriosis. What is the primary mechanism that accounts for its therapeutic effect?

15. Mifepristone (RU-486), used for medical termination of pregnancy, acts as a:

16. GnRH agonists like Leuprolide are used to treat endometriosis and uterine fibroids. What is the physiological effect of their continuous administration?

17. A 28-week pregnant woman presents in preterm labour. Administration of Betamethasone is indicated to:

18. What is the recommended first-line treatment for Chlamydia trachomatis infection in a pregnant woman?

19. Carboplatin is often preferred over Cisplatin in ovarian cancer chemotherapy regimens because it has:

20. Paclitaxel, a taxane used in gynaecological cancers, exerts its cytotoxic effect by:

21. The drug of choice for treating bacterial vaginosis, characterized by a ‘fishy’ odour and clue cells on microscopy, is:

22. What is the primary contraceptive mechanism of action of the progestin-only pill (mini-pill)?

23. A pregnant patient with severe pre-eclampsia develops a hypertensive crisis with a blood pressure of 170/115 mmHg. Which intravenous drug is a first-line agent for acute management?

24. Bevacizumab (Avastin) is a monoclonal antibody used in the treatment of recurrent or metastatic cervical and ovarian cancer. What is its mechanism of action?

25. Raloxifene is a SERM used for osteoporosis prevention in postmenopausal women. Compared to Tamoxifen, it has a lower risk of causing: