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1. The number of double bones in polyene, antibiotic, amphotericin B is
- (a) 4
- (b) 5
- (c) 7
- (d) 6
Answer- (c) 7
2. Norfloxacin, quinolone derivative
- (a) is only effective against Proteus SPS.
- (b) possess a broad spectrum of activity
- (c) is only effective against gram-positive microorganisms
- (d) None of the above
Answer-(b) possess a broad spectrum of activity
3. Cycloserine is stereochemically related to amino acid
- (a) L-alanine
- (b) D-serine
- (c) D-alanine
- (d) D-phenylalanine
Answer-(b) D-serine
4. Identify the odd one regarding rifampin
- (a) Rifampin possesses the macrocyclic ring
- (b) It is moisture sensitive
- (c) Its metabolic product, deacetyl rifampin is also active
- (d) Resistance toward rifampicin is not developed readily
Answer- (d) Resistance toward rifampicin is not developed readily
5. The absolute stereochemistry of penicillins is designated as
- (a) 3S: 5R: 6R
- (c) 3S5S: 6S
- (b) 3R: 5R: 6R
- (d) 3S: 5R: 6S
Answer-(a) 3S: 5R: 6R
6. Benizyl penicillin is not suitable for oral administration because
- (a) it is metabolized rapidly
- (b) its absorption is poor in the GIT tract
- (c) it is degraded in the stomach
- (d) it contains the allyl group at the C-6 position
Answer-(c) it is degraded in the stomach
7. The ampicillin is stable in acidic solution because
- (a) it contains amino groups at a position
- (b) it has broad-spectrum activity
- (c) it contains an allyl group at a position
- (d) it is the basic drug
Answer- (a) it contains amino groups at a position
8. The stability of enzyme penicillinase is increased by
- (a) causing the steric hindrance at the a-carbon of the acyl group
- (b) placing an electron-withdrawing group at the a-carbon of the acyl group
- (c) placing an electron-donating group
- (d) None of the above
Answer- (a) causing the steric hindrance at the a-carbon of the acyl group
9. Which one of these is acid as well as penicillinase-resistant?
- (a) Dicloxacillin
- (b) Carbenicillin
- (c) Melhicillin
- (d) Amoxicillin
Answer-(a) Dicloxacillin
10. The spectrum of activity of penicillin can be increased by
- (a) placing an electron-withdrawing group at the a-carbon atom of the acyl group
- (b) placing a polar group at a-carbon of an acyl group
- (c) causing a steric hindrance at a-carbon of an acyl group
- (d) None of the above
Answer-(b) placing a polar group at a-carbon of an acyl group
11. Which one of these is a-acylureido substituted penicillin?
- (a) Ampicillin
- (b) Amoxicillin
- (c) Mezlocillin
- (d) Cloxacillin
Answer-(c) Mezlocillin
12. Which one of these penicillin does not possess a broad spectrum of activity?
- (a)
- (b) Piperacillin
- (c) Amoxicillin
- (d) Nafcillin
Answer-(c) Amoxicillin
13. Dicloxacillin is named as
- (a) 3-(0-Chlorophenyl)-5-methyl-4-isoxazolyl penicillin
- (b) 3-(2, 6-Dichlorophenyl)-5-methyl-4-isoxazolyl penicillin
- (c) 5-Methyl-(3-phenyl-4-isoxazolyl) penicillin
- (d) 3-(2,5-Dichlorophenyl)-5-methyl-4-isoxazolyl penicillin
Answer-(b) 3-(2, 6-Dichlorophenyl)-5-methyl-4-isoxazolyl penicillin
14. The IUPAC name of ampicillin is
- (a) 6-[D-a-Aminophenyl acetamido] penicillanic acid
- (b) 6-[L-a-Aminophenyl acetamido] acid
- (c) 6-[D-a-amhiophenyl benzamido] penicillanic acid
- (d) None of the above
Answer-(a) 6-[D-a-Aminophenyl acetamido] penicillanic acid
15. The penicillins are named as
- (a) 4-Thia-1-azabicyclo (3, 2, 1) heptanes
- (b) 4-Thia-1-azacyclo (3, 2, 0) heptanes
- (c) 4-Thia-1-azabicyclo (3, 2, 1) heptanes
- (d) 4-Thia-1-azabicyclo (2, 2, 0) heptanes
- Answer-(b) 4-Thia-1-azacyclo (3, 2, 0) heptanes
16. Which one of these is a 1-oxopenam derivative?
- (a) Clavanic acid
- (b) Thienamycin
- (c) Cefradoxine
- (d) Nafcillin
Answer-(a) Clavanic acid
17. Which is a 2-carbapenem derivative?
- (a) Clavulanate potassium
- (b) Thienamycin
- (c) Sulbactam
- (d) All of the above
Answer-(b) Thienamycin
18. The cephalosporin is designated as
- (a) 4-Thia-1-azabicyclo [4, 2, 0] oct-2-ene
- (b) 4-Thia-1-azabicyclo [4, 2, 1] oct-2-ene
- (c) 4-Thia-1-azabicyclo [4, 3, 1] oct-2-ene
- (d) 4-Thia-1-azabicyclo [3, 3, 1] oct-2-ene
Answer-(a) 4-Thia-1-azabicyclo [4, 2, 0] oct-2-ene
19. Streptomycin on hydrolysis gives
- (a) Streptidine + L-Streptose + L-glucosamine
- (b) L-streptose + L-glucosamine
- (c) Streptidine + L-Streptose + N-methyl-L-glucosemine
- (d) None of the above
Answer- (c) Streptidine + L-Streptose + N-methyl-L-glucosemine
20. Oxytetracycline is a derivative of
- (a) Hydronapthacene
- (b) Octahydronapthacene
- (c) Hexahydronapthacene
- (d) Decahydronapthacene
Answer- (b) Octahydronapthacene
21. The tetracycline is
- (a) acidic in nature
- (b) neutral in nature
- (c) basic in nature
- (d) amphoteric in nature
Answer- (a) acidic in nature
22. Epitetracycline is formed due to epimerization which takes place at
- (a) C-4 in acidic PH
- (b) C-2 in acidic PH
- (c) C-10 in acidic PH
- (d) C-11a in acidic PH
Answer-(a) C-4 in acidic PH
23. Anhydrotetracyclines are formed by the attack of strong acid/base on tetracycline possessing
- (a) 3-hydroxyl group
- (b) 4-hydroxyl group
- (c) 11-hydroxyl group
- (d) 6-hydroxyl group
Answer- (d) 6-hydroxyl group
24. The dimethylamino group at 4-position in tetracycline has
- (a) a-orientation
- (b) B-orientation
- (c) a- or B-orientation depending on individual tetracycline
- (d) none of the above
Answer-(a) a-orientation
25. In which tetracycline, the amide group at 2-position is substituted
- (a) Demeclocycline
- (b) Doxycycline
- (c) Minocycline
- (d) Rolitetracycline
Answer-(d) Rolitetracycline
26. IUPAC name of tetracycline is
- (a) 4-dimethyulamino-1, 4, 4a, 5, 5a, 6, 12a-octa napthacene
- (b) 4-dimethylamino-1, 4, 4a, 5, 5a, 6, 12a-octahydro 3, 6, 10, 12, 12a – pentahydroxy – 6 -methyl-1, 11-dioxo – 2 naphthacene carbonamide
- (c) 4-Amino-1, 4, 4a, 5, 5a, 6, 12a-oct a hydro-3, 6, 10, 12, 12a-pentahydromy-6-methyl 1, 11-dioxo-2-naphthacene carbonamide
- (d) None of the above
Answer-(b) 4-dimethylamino-1, 4, 4a, 5, 5a, 6, 12a-octahydro 3, 6, 10, 12, 12a – pentahydroxy – 6 -methyl-1, 11-dioxo – 2 naphthacene carbonamide
27. Tetracyclines medicinal chemistry question at C-4 between pH4 and 8 to give
- (a) Isotetracyclines
- (b) Epitetracyclines
- (c) Nor tetracyclines
- (d) none of the above
Answer-(b) Epitetracyclines
28. Morphine and heroin differ from each other in respect of
- (a) Methyl group on Nitrogen
- (b) Acetylgioup at C, and C
- (c) Absence of double bond between C, and C
- (d) Absence of D ring
Answer-(b) Acetylgioup at C, and C
29. 3- Etherification of morphine molecule causes
- (a) Morphine antagonism
- (b) No change in activity
- (c) Decrease in analgesic and addiction.
- (d) Increase in analgesic and addiction
Answer- (c) Decrease in analgesic and addiction.
30. D-a-Aminobenzylpenicillin is a chemical name for
- (a) Amoxicillin
- (b) Ampicillin
- (c) Azlocillin
- (d) None of the above
Answer- (b) Ampicillin
31. C17 a, Bunsaturated lactone ring is a common feature in
- (a) Digitalis and squil glycosides
- (b) Digitalis and strophanthus glycosides.
- (c) Digitalis and semna glycosides
- (d) Digitalis and amygdalin
Answer- (b) Digitalis and strophanthus glycosides.
32. Chemical name of Amoxicillin is
- (a) 6-[D-(-) a – amino p-hydroxy phenyl acetamido] pencillanic acid
- (b) 4-[D-(-) a-amino p-hydroxy phenyl acetamido] pencillanic acid
- (c) B-Hydroxy analogue of Benzylpenicillin
- (d) a-Carboxy benzylpenicillin
Answer-(b) 4-[D-(-) a-amino p-hydroxy phenyl acetamido] pencillanic acid
33. Acidity of Ascorbic acid is due to the presence of
- (a) free carboxylic acid
- (b) a number of hydroxyl groups
- (c) enolic groups
- (d) None of the above
Answer- (c) enolic groups
34. Vitamin D, is
- (a) 22,23-dihydro-5, 6-cisergocalciferol
- (b) 5, 6-cis- cholecaliciferol
- (c) 7-dehydrocholesterol
- (d) 21, 24-dihydro-5, 6- cis ergocalciferol
Answer- (a) 22,23-dihydro-5, 6-cisergocalciferol
35. Erythromycin is a macrolide antibiotic due to specific chemical features. Identify it
- (a) Large size lactone ring
- (b) Ketone group
- (c) Glycosidically linked amino sugar
- (d) Double bond
Answer- (a) Large size lactone ring
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36. The optimum pH for the stability of erythromycin is
- (a) 4-5
- (b) 6.5 to 7.5
- (c) 9
- (d) 11
Answer- (b) 6.5 to 7.5
37. Which antibiotic contains a sulfur atom?
- (a) Erythromycin
- (b) Lincomycin
- (c) Tobramycin
- (d) Kanamycin
Answer- (b) Lincomycin
38. Commercial bacitracin is a mixture of
- (a) F (major amount) and the smaller amount of A, B, D, E, and F
- (b) B (major amount) and a smaller amount of A, B, D, E, and F
- (c) A (major amount) and a smaller amount of B, D, E, and F
- (d) D (major amount) and a smaller amount of A, B, E, and F
Answer- (c) A (major amount) and a smaller amount of B, D, E, and F
39. Polymyxin B sulfate is frequently combined with bacitracin for topical application because
- (a) it is only effective in presence of bacitracin
- (b) the activity of polymyxim B is increased due to the synergistic effect caused by bacitracin
- (c) the spectrum of activity is increased as polymyxin B sulfate is only effective against the negative organism
- (d) the toxicity of polymyxin is decreased
Answer- (c) the spectrum of activity is increased as polymyxin B sulfate is only effective against the negative organism
40. The chloramphenicol is named as
- (a) 2,3-Dichloro-N [a-hydroxy-methyl) B-hydroxy-p-nitrophenyl acetamide
- (b) 2,2-Dichloro-N [B-hydroxymethyl B-hydroxy-p-nitrophenyl acetamide
- (c) 1,2-Dichloro-N-[a-hydroxy methyl] B-hydroxy-p-nitrophenyl acetamide
- (d) 1,2-Dichloro-N [a-hydroxy methyl] B-hydroxy-p-nitrophenyl benzamide
Answer- (a) 2,3-Dichloro-N [a-hydroxy-methyl) B-hydroxy-p-nitrophenyl acetamide
41. Four isomers of chloramphenicol are possible due to the presence of two asymmetric carbon atoms. Identify the
- (a) L- thero isomers biologically active isomer
- (b) L-threo isomer
- (c) D- Erythro isomer
- (d) D- Erythro isomer
Answer- (a) L- thero isomers biologically active isomer
42. Chloramphenicol on hydrolysis in presence of acid gives
- (a) 1-(p-nitrophenyl)-1-aminopropan-1, 3-diol and dichloroacetic acid
- (b) 1-(p-nitrophenyl)-2-aminopropan-1, 3-diol and dichloroacetic acid
- (c) 1-(p-nitrophenyl)-2-aminopropan-1, 3-diol and chloroacetic acid
- (d) 1-(p-nitrophenyl) – 1-aminopropan-1, 2-diol and dichloroacetic acid
Answer- (b) 1-(p-nitrophenyl)-2-aminopropan-1, 3-diol and dichloroacetic acid
43. Which antibiotic is beneficial in Rocky Mountain spotted fever?
- (a) Lincomycin
- (b) Chloramphenicol
- (c) Polymyxin B Sulphate
- (d) Novobiocin
Answer- (c) Polymyxin B Sulphate
44. The actinomycins used in cancer therapy contain the same chromophoric moiety. Identify it
- (a) 2-Phenoxazone-1, 9-dicarboxylic acid
- (b) 3-Phenaxazone-1, 9- dicarboxylic acid
- (c) 3 – Phenoxazone – 1, 8- dicarbo-xylic acid
- (d) none of the above
Answer- (b) 3-Phenaxazone-1, 9- dicarboxylic acid
45. Daunorubicin contain
- (a) Anthraquinone
- (b) Macrolide ring
- (d) Anthra cyclone
Answer- (d) Anthra cyclone
46. Which enzyme is effective in the treatment of acute lymphocytic leukemia?
- (a) Lyase
- (b) Asparaginase
- (c) Adenyl cyclase
- (d) Xanthine oxidase
Answer- (b) Asparaginase
47. Picrotoxin is analeptic agent. It acts by
- (a) inhibiting the enzyme MAO
- (b) interfering in the GABA activity
- (c) interfering in the serotonin
- (d) none of the above
Answer- (b) interfering in the GABA activity
48. Pseudoephedrine is a
- (a) Erythro isomer
- (b) Threo isomer
- (c) Mero isomer
- (d) Racemic mixture
Answer- (b) Threo isomer
49. Pregnenolone, an intermediate in the synthesis of steroids on oppeneur oxidation gives
- (a) Progesterone
- (b) 9a-Flurocortisol
- (c) Triamcinolone
- (d) a-Methyl prednisolone
Answer- (a) Progesterone
50. Testosterone can be commercially synthesized from
- (a) Sarsasapogenin
- (b) Mexogenin
- (c) Qubagenin
- (d) Halotensin
Answer- (a) Sarsasapogenin
51. Erythromycin is an antibiotic. It belongs to the class of
- (a) Blactam
- (b) Aminoglycoside
- (c) Macrolide
- (d) Peptide
Answer- (c) Macrolide
52. The 5p pregnane nucleus is said to have a
- (a) trans- anti trans c – anti-trans
- (b) cis-anti trans anti trans
- (c) cis- syn-trans- syn – trans
- (d) trans- anti – cis – anti- cis
Answer- (b) cis-anti trans anti trans
53. D-Fructose on simple reduction gives
- (a) only mannitol
- (b) only sorbitol
- (c) L-fructose
- (d) the mixture of mannitol and sorbitol
Answer- (d) the mixture of mannitol and sorbitol
54. The ‘Hemiacetal’ form of aldosterone is between
- (a) C-11, B-hydroxyl and C-20 carbonyl
- (b) C-11, B-hydroxyl and C-21 carbonyl
- (c) C-11, B-hydroxyl and C – 18 carbonyl
- (d) C-21 hydroxyl and C-20 carbonyl
Answer- (c) C-11, B-hydroxyl and C – 18 carbonyl
55. The active ergot alkaloid differs from the inactive one only differ in
- (a) functional group at 1-position
- (b) configuration at position 8 of the molecule
- (c) saturation between positions 9 and 10
- (d) Solubility in water
Answer- (b) configuration at position 8 of the molecule
56. Which is a prototype drug in cholinergic blocker?
- (a) Atropine
- (b) Cocaine
- (c) Hyoscyamine
- (d) Homatropine
Answer- (a) Atropine
57. Which one of these is an amino alcohol ester, used as a cholinergic blocker?
- (a) Ipratropium bromide
- (b) Ethopropazine hydrochloride
- (c) Cyclopentolate hydrochloride
Answer- (c) Cyclopentolate hydrochloride
58. IUPAC name for papaverine is
- (a) 4,5-dimethoxy – 1 – veratryl isoquinoline
- (b) 3,4-dimethoxy – 1 – veratryl isoquinoline
- (c) 6,7-dimethoxy – 1 – veratryl isoquinoline
- (d) 5,6-dimethoxy – I – veratryl isoquinoline
Answer- (c) 6,7-dimethoxy – 1 – veratryl isoquinoline
59. The curare-like activity is a common property of all ‘onium’ compounds. The activity decreases in the following order
- (a) (CH₂)₂N+> (CH₂), St> (CH₂), P+
- (b) (CH₂),S*> (CH₂), N*> (CH₂), P+
- (c) (CH,),N>(CH,), P* > (CH,), S*
- (d) (CH,) P*>(CH,),S*>(CH,),N*
Answer- (a) (CH₂)₂N+> (CH₂), St> (CH₂), P+
60. Tubocurarine chloride is
- (a) (+)-Tubocurarine chloride
- (b) (-)- Tubocurarine chloride
- (c) meso-tubocurarine chloride
- (d) recemic-tubocurarine chloride
Answer- (a) (+)-Tubocurarine chloride
61. B-sitosterol is beneficial in the treatment of hyperlipoproteinemias. It differs from cholesterol in one aspect. Identify it
- (a) B-sitosterol contains an ethyl group at the C-24 position
- (b) B-sitosterol does not contain a double bond
- (c) Methyl group at C-19 position is not present
- (d) Hydroxy group is esterified
Answer-(a) B-sitosterol contains an ethyl group at the C-24 position
62. Liothyronine is
- (a) O-[4-hydroxy-3, 5- diiodophenyl) 3, 5 – diiodo – 2 – tyrosine
- (b) 0-[4-hydroxy-3- iodophenyl) 3,5-diiodo – L – tyrosine
- (c) O-[4-hydroxy-3- iodophenyl) 3, 5-diiodo – D – tyrosine
- (d) O-[4-hydroxy – 2- iodophenyl) 3, 5- diiodo – D – tyrosine
Answer- (b) 0-[4-hydroxy-3- iodophenyl) 3,5-diiodo – L – tyrosin
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