Fluorescein Staining for Corneal Pathology MCQ Quiz | Clinical Skills & Procedures

1. What is the fundamental principle of fluorescein staining for assessing corneal integrity?

2. Which type of light and filter combination is essential for optimal visualization of fluorescein staining on the cornea?

3. A positive Seidel’s test, characterized by a “waterfall” or “rivulet” sign, indicates what specific pathology?

4. A Tear Break-Up Time (TBUT) of less than 10 seconds is generally considered abnormal and is indicative of:

5. A patient presents with a painful red eye. Fluorescein staining reveals a linear, branching, tree-like pattern with terminal bulbs. This finding is pathognomonic for:

6. What does “negative staining” with fluorescein refer to?

7. Which of the following is a major contraindication for instilling fluorescein drops in an eye?

8. The Jones I test uses fluorescein to assess the patency of which structure?

9. Diffuse, fine, dot-like staining across the cornea, known as Punctate Epithelial Erosions (PEE), is a non-specific finding that can be caused by:

10. What is the main difference in staining properties between fluorescein and Rose Bengal/Lissamine Green?

11. In a case of exposure keratopathy, where would you most likely expect to find fluorescein staining?

12. A corneal ulcer typically stains with fluorescein in a specific way. How does it differ from a simple abrasion?

13. What is the preferred method for applying fluorescein to the eye to minimize the risk of contamination?

14. In filamentary keratitis, what specific structures are highlighted by fluorescein staining?

15. A large, non-healing epithelial defect that stains with fluorescein in a patient with a history of diabetes and reduced corneal sensation is highly suggestive of:

16. The phenomenon where high concentrations of fluorescein can lead to a decrease in fluorescence intensity is known as:

17. After removing a metallic corneal foreign body, you notice a ring-like structure at the site that stains with fluorescein. This is most likely:

18. Superior Limbic Keratoconjunctivitis (SLK) is characterized by fluorescein staining in which specific location?

19. What is the role of the preservative, such as benoxinate hydrochloride, often combined with fluorescein in multi-dose preparations?

20. In the context of fitting rigid gas permeable (RGP) contact lenses, what does an area of central blackness (no fluorescence) under the lens indicate?

21. A patient complains of foreign body sensation. Fluorescein staining shows multiple short, vertical linear scratches on the superior cornea. This pattern is highly suggestive of:

22. Which layer of the cornea is highly lipophilic and acts as the primary barrier preventing fluorescein from penetrating a healthy eye?

23. In a severe corneal chemical burn, a complete lack of fluorescein staining (a “white-out” cornea) might indicate:

24. What is the key difference between topical fluorescein staining for corneal pathology and intravenous fluorescein angiography (IVFA)?

25. A patient with recurrent corneal erosions might show fluorescein staining after waking up. The underlying pathology is often a weak attachment between which two corneal layers?