Constipation MCQ Quiz | Gastrointestinal System

1. According to the Rome IV criteria for functional constipation in adults, which of the following is required for diagnosis?

2. A 70-year-old male presents with a 2-month history of constipation, unintentional weight loss of 5 kg, and rectal bleeding. What is the most appropriate next step in management?

3. Which class of laxatives works by increasing fecal mass and stimulating peristalsis?

4. A patient with chronic constipation who strains excessively and reports a sensation of anorectal blockage is most likely suffering from which subtype of primary constipation?

5. Which of the following medications is a common cause of drug-induced constipation by reducing gut motility via mu-opioid receptor agonism?

6. A patient with refractory constipation undergoes a colonic transit study (Sitzmarks test), which shows markers clustered in the rectosigmoid region. This finding is most suggestive of:

7. Prucalopride is an effective treatment for chronic constipation. What is its primary mechanism of action?

8. Which of the following is a potential metabolic complication of chronic laxative abuse, particularly with stimulant laxatives?

9. An elderly, bedridden patient presents with nausea, abdominal distension, and passage of liquid “overflow” diarrhea. On digital rectal examination, a hard mass of stool is felt. What is the most likely diagnosis?

10. Linaclotide and plecanatide are used for chronic idiopathic constipation and IBS-C. They work by activating which enzyme on the luminal surface of intestinal enterocytes?

11. A 45-year-old woman with scleroderma presents with severe constipation. This is most likely due to:

12. Which of the following endocrine disorders is a well-established secondary cause of constipation?

13. In the management of opioid-induced constipation (OIC), which medication class is specifically designed to target the underlying pathophysiology without reversing central analgesia?

14. What is the primary role of anorectal manometry in the evaluation of a patient with chronic constipation?

15. A 30-year-old pregnant woman in her third trimester complains of worsening constipation. This is primarily attributed to increased levels of which hormone?

16. The most common type of chronic primary constipation is:

17. Which neurological condition is strongly associated with constipation, often preceding motor symptoms by several years?

18. The mechanism of action of Lubiprostone involves the activation of:

19. What is the recommended daily dietary fiber intake for adults to help prevent and manage constipation?

20. Which of these is NOT considered an “alarm feature” warranting further investigation in a patient with constipation?

21. A patient with end-stage renal disease develops constipation. Which laxative should be used with caution due to the risk of accumulation and toxicity?

22. Hirschsprung’s disease, a cause of congenital constipation, is characterized by the absence of which cells in the distal colon?

23. Biofeedback therapy is most effective for which type of chronic constipation?

24. What is the mechanism of action of docusate salts?

25. First-line management for most cases of functional constipation, after ruling out secondary causes and alarm features, typically involves: