Chorea – Basics MCQ Quiz | Central Nervous System

1. Chorea is best described as which type of involuntary movement?

2. The primary neuroanatomical substrate for chorea is dysfunction of the:

3. The pathophysiology of chorea typically involves a relative excess of which neurotransmitter’s activity in the basal ganglia?

4. What is the mode of inheritance for Huntington’s disease?

5. Sydenham’s chorea is a major manifestation of which condition?

6. Huntington’s disease is caused by an expanded trinucleotide repeat of:

7. Hemichorea, a unilateral chorea, is most commonly associated with a lesion in the:

8. Which of the following drugs is classically associated with causing iatrogenic chorea, especially in patients with Parkinson’s disease?

9. The “milkmaid’s grip” (alternating grip pressure) and the inability to maintain tongue protrusion are clinical signs of:

10. The term for chorea that develops during pregnancy and typically resolves after delivery is:

11. Wilson’s disease can present with chorea due to the toxic accumulation of which element in the basal ganglia?

12. A characteristic finding on MRI or CT scans in advanced Huntington’s disease is:

13. The organism indirectly responsible for the autoimmune reaction leading to Sydenham’s chorea is:

14. A first-line symptomatic treatment for chorea, which works by depleting presynaptic dopamine via VMAT2 inhibition, is:

15. While often co-occurring (choreoathetosis), athetosis is distinguished from pure chorea by being more:

16. Chorea can be a rare but recognized neurological manifestation of which autoimmune disorder?

17. In the direct pathway of the basal ganglia, which is thought to be overactive in chorea, the striatum projects inhibitory signals to the:

18. A form of choreoathetoid movement disorder that can arise from long-term use of dopamine receptor blocking agents (antipsychotics) is known as:

19. Which of the following endocrine disorders is a known metabolic cause of chorea?

20. The typical age of onset for motor symptoms in Huntington’s disease is:

21. A 45-year-old patient presents with a progressive movement disorder, cognitive decline, and significant personality changes. The triad of chorea, dementia, and psychiatric disturbance is classic for:

22. The most severe and violent form of chorea, characterized by large-amplitude, flinging movements of the proximal limbs, is called:

23. A useful laboratory test to support the diagnosis of Sydenham’s chorea is:

24. In Huntington’s disease, there is selective neuronal loss, particularly of medium spiny neurons that use GABA, in the:

25. The pathophysiology of chorea, particularly in Huntington’s disease, is most commonly associated with degeneration of neurons in which basal ganglia pathway?