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Mechanism of Action of SGLT2 Inhibitors

May 31, 2025 by Harsh Singh Rajput
SGLT2 inhibitors mechanism – increased glucose excretion via renal tubules

Introduction SGLT2 Inhibitors, or sodium-glucose co-transporter 2 inhibitors, are a newer class of oral antidiabetic drugs that reduce … Read more

Mechanism of Action of DPP-4 Inhibitors

May 31, 2025 by Harsh Singh Rajput
DPP-4 inhibitors mechanism – incretin hormone enhancement via enzyme blockade

Introduction Dipeptidyl Peptidase-4 (DPP-4) Inhibitors, commonly referred to as gliptins, are oral antidiabetic drugs that enhance the action … Read more

Mechanism of Action of Thiazolidinediones

May 31, 2025 by Harsh Singh Rajput
TZD mechanism – PPAR gamma activation and insulin sensitivity improvement

Introduction Thiazolidinediones (TZDs), also known as glitazones, are oral antidiabetic drugs used to improve insulin sensitivity in patients … Read more

Mechanism of Action of Meglitinides

July 4, 2025May 31, 2025 by Harsh Singh Rajput
Meglitinides mechanism – insulin secretion by SUR1-mediated KATP channel blockade

Introduction Meglitinides, also known as glinides, are short-acting insulin secretagogues used in the treatment of type 2 diabetes … Read more

Mechanism of Action of Sulfonylureas

May 31, 2025 by Harsh Singh Rajput
Sulfonylureas mechanism – insulin secretion via KATP channel inhibition

Introduction Sulfonylureas are one of the oldest and most widely used classes of oral antidiabetic agents. They are … Read more

Mechanism of Action of Potassium-Sparing Diuretics

May 31, 2025 by Harsh Singh Rajput
Potassium-sparing diuretics mechanism – aldosterone antagonism and ENaC blockade

Introduction Potassium-sparing diuretics are a unique subclass of diuretics that help conserve potassium levels while promoting mild diuresis. … Read more

Mechanism of Action of Thiazide Diuretics

May 30, 2025 by Harsh Singh Rajput
Thiazide diuretics mechanism – inhibition of sodium chloride symporter in the distal tubule

Introduction Thiazide diuretics are one of the most commonly prescribed classes of antihypertensive agents, especially in the U.S. … Read more

Mechanism of Action of Beta-Blockers

May 30, 2025May 30, 2025 by Harsh Singh Rajput
Beta-blockers mechanism of action – antagonism of beta-adrenergic receptors reducing heart rate and contractility

Introduction Beta-blockers are a widely used class of drugs in cardiovascular medicine. They block the effects of catecholamines, … Read more

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