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Mechanism of Action of Typical Antipsychotics (First-Generation)

June 3, 2025 by Harsh Singh Rajput
Typical antipsychotics MOA – D2 receptor antagonism in mesolimbic pathway

Introduction Typical antipsychotics, also known as first-generation antipsychotics (FGAs), are primarily used to treat schizophrenia, acute psychosis, and … Read more

Mechanism of Action of Benzodiazepines

June 3, 2025 by Harsh Singh Rajput
Benzodiazepines mechanism – GABA-A receptor binding and CNS depression

Introduction Benzodiazepines are a class of psychoactive drugs widely used for their anxiolytic, sedative, hypnotic, anticonvulsant, and muscle … Read more

Mechanism of Action of Tricyclic Antidepressants (TCAs)

May 31, 2025 by Harsh Singh Rajput
TCA mechanism – serotonin and norepinephrine reuptake inhibition with receptor blockade

Introduction Tricyclic antidepressants (TCAs) are one of the oldest classes of antidepressant medications. Although largely replaced by SSRIs … Read more

Mechanism of Action of SGLT2 Inhibitors

May 31, 2025 by Harsh Singh Rajput
SGLT2 inhibitors mechanism – increased glucose excretion via renal tubules

Introduction SGLT2 Inhibitors, or sodium-glucose co-transporter 2 inhibitors, are a newer class of oral antidiabetic drugs that reduce … Read more

Mechanism of Action of DPP-4 Inhibitors

May 31, 2025 by Harsh Singh Rajput
DPP-4 inhibitors mechanism – incretin hormone enhancement via enzyme blockade

Introduction Dipeptidyl Peptidase-4 (DPP-4) Inhibitors, commonly referred to as gliptins, are oral antidiabetic drugs that enhance the action … Read more

Mechanism of Action of Thiazolidinediones

May 31, 2025 by Harsh Singh Rajput
TZD mechanism – PPAR gamma activation and insulin sensitivity improvement

Introduction Thiazolidinediones (TZDs), also known as glitazones, are oral antidiabetic drugs used to improve insulin sensitivity in patients … Read more

Mechanism of Action of Meglitinides

July 4, 2025May 31, 2025 by Harsh Singh Rajput
Meglitinides mechanism – insulin secretion by SUR1-mediated KATP channel blockade

Introduction Meglitinides, also known as glinides, are short-acting insulin secretagogues used in the treatment of type 2 diabetes … Read more

Methotrexate – Mechanism of Action

May 26, 2025May 25, 2025 by Harsh Singh Rajput
Flowchart of Methotrexate mechanism of action showing DHFR inhibition and suppression of DNA synthesis in S-phase

Introduction Methotrexate is a cornerstone drug in both anticancer chemotherapy and immunosuppressive therapy. Structurally, it is a folic … Read more

Aspirin – Mechanism of Action

May 26, 2025May 25, 2025 by Harsh Singh Rajput
Stepwise mechanism of action of Aspirin showing COX inhibition and antiplatelet effect

Introduction Aspirin, also known as acetylsalicylic acid, is a widely used Non-Steroidal Anti-Inflammatory Drug (NSAID). It’s primarily known … Read more

MCQ Quiz- Determinants of Health

May 24, 2025 by G S Sachin
MCQ QUIZ- DETERMINANTS OF HEALTH

Determinants of health shape the conditions in which people live, grow, and age. For pharmacists, understanding these factors … Read more

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