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Mechanism of Action of Amiodarone (Class III Antiarrhythmic)

June 23, 2025 by Harsh Singh Rajput
Amiodarone MOA – Multi-class antiarrhythmic with K⁺ channel blockade

Introduction Amiodarone is a powerful Class III antiarrhythmic agent used to treat various life-threatening cardiac arrhythmias, including ventricular … Read more

Mechanism of Action of Warfarin (Vitamin K Antagonist)

June 23, 2025 by Harsh Singh Rajput
Warfarin MOA – Inhibition of vitamin K-dependent clotting factors

Introduction Warfarin is a widely used oral anticoagulant that inhibits the synthesis of vitamin K-dependent clotting factors. It … Read more

Mechanism of Action of Colchicine (Anti-inflammatory in Gout)

June 23, 2025 by Harsh Singh Rajput
Colchicine MOA – Inhibition of microtubule polymerization in neutrophils

Introduction Colchicine is an anti-inflammatory drug primarily used in the management of acute gouty arthritis, familial Mediterranean fever, … Read more

Mechanism of Action of Clopidogrel (Antiplatelet Agent)

June 23, 2025 by Harsh Singh Rajput
Clopidogrel MOA – P2Y12 Receptor Inhibition on Platelets

Introduction Clopidogrel is a widely used oral antiplatelet drug belonging to the thienopyridine class. It plays a critical … Read more

Mechanism of Action of Proton Pump Inhibitors (PPIs)

June 23, 2025 by Harsh Singh Rajput
Proton Pump Inhibitor MOA – H⁺/K⁺ ATPase Inhibition

Introduction Proton Pump Inhibitors (PPIs) are potent acid-suppressing drugs widely used in the treatment of gastric and duodenal … Read more

Mechanism of Action of Metronidazole (DNA-Damaging Antibiotic)

June 23, 2025June 22, 2025 by Harsh Singh Rajput
Metronidazole MOA – DNA damage via nitro radical formation

Introduction Metronidazole is a unique antibiotic and antiprotozoal agent that exerts its action by damaging DNA in anaerobic … Read more

Mechanism of Action of Sulfonamides (Folic Acid Synthesis Inhibitors)

June 23, 2025June 21, 2025 by Harsh Singh Rajput
Sulfonamide MOA – Folic acid synthesis inhibition via dihydropteroate synthase

Introduction Sulfonamides are synthetic bacteriostatic antibiotics that inhibit folic acid synthesis in bacteria. Because mammals obtain folate from … Read more

Mechanism of Action of Glycopeptides (e.g., Vancomycin)

June 23, 2025June 21, 2025 by Harsh Singh Rajput
Vancomycin MOA – D-Ala-D-Ala binding and peptidoglycan inhibition

Introduction Glycopeptides, most notably vancomycin, are a class of bactericidal antibiotics that inhibit bacterial cell wall synthesis by … Read more

Mechanism of Action of Tetracyclines (Broad-Spectrum 30S Ribosome Inhibitors)

June 23, 2025June 21, 2025 by Harsh Singh Rajput
Tetracycline MOA – 30S ribosome binding and tRNA blocking

Introduction Tetracyclines are a class of broad-spectrum bacteriostatic antibiotics that inhibit bacterial protein synthesis. Common examples include tetracycline, … Read more

Mechanism of Action of Aminoglycosides

July 4, 2025June 20, 2025 by Harsh Singh Rajput
Aminoglycoside MOA – 30S ribosomal subunit binding and mRNA misreading

Introduction Aminoglycosides are potent bactericidal antibiotics used mainly against aerobic Gram-negative bacilli and serious systemic infections. Common examples … Read more

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