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USMLE

Mechanism of Action of Glycopeptides (e.g., Vancomycin)

June 23, 2025June 21, 2025 by Harsh Singh Rajput
Vancomycin MOA – D-Ala-D-Ala binding and peptidoglycan inhibition

Introduction Glycopeptides, most notably vancomycin, are a class of bactericidal antibiotics that inhibit bacterial cell wall synthesis by … Read more

Mechanism of Action of Tetracyclines (Broad-Spectrum 30S Ribosome Inhibitors)

June 23, 2025June 21, 2025 by Harsh Singh Rajput
Tetracycline MOA – 30S ribosome binding and tRNA blocking

Introduction Tetracyclines are a class of broad-spectrum bacteriostatic antibiotics that inhibit bacterial protein synthesis. Common examples include tetracycline, … Read more

Mechanism of Action of Aminoglycosides

June 23, 2025June 20, 2025 by Harsh Singh Rajput
Aminoglycoside MOA – 30S ribosomal subunit binding and mRNA misreading

Introduction Aminoglycosides are potent bactericidal antibiotics used mainly against aerobic Gram-negative bacilli and serious systemic infections. Common examples … Read more

Mechanism of Action of Fluoroquinolones (DNA Gyrase and Topoisomerase Inhibitors)

June 23, 2025June 20, 2025 by Harsh Singh Rajput
Fluoroquinolone MOA – Inhibition of DNA gyrase and topoisomerase

Introduction Fluoroquinolones are a powerful class of bactericidal antibiotics that inhibit bacterial DNA replication. They are widely used … Read more

Mechanism of Action of Macrolides (Protein Synthesis Inhibitor Antibiotics)

June 23, 2025June 20, 2025 by Harsh Singh Rajput
Macrolide MOA – 50S ribosome binding and protein synthesis inhibition

Introduction Macrolides are a widely used class of bacteriostatic antibiotics that inhibit bacterial protein synthesis. They are especially … Read more

Mechanism of Action of Penicillins (β-lactam Antibiotics)

June 23, 2025June 19, 2025 by Harsh Singh Rajput
Penicillins MOA – Cell wall synthesis inhibition

Introduction Penicillins are one of the oldest and most widely used classes of antibiotics, belonging to the β-lactam … Read more

Mechanism of Action of Lacosamide (Newer Antiepileptic Drug)

June 23, 2025June 18, 2025 by Harsh Singh Rajput
Lacosamide MOA – Enhances slow inactivation of sodium channels in epilepsy

Introduction Lacosamide is a newer-generation antiepileptic drug (AED) used for the treatment of focal (partial) seizures and adjunctive … Read more

Mechanism of Action of Gabapentin

June 3, 2025 by Harsh Singh Rajput
Gabapentin MOA – calcium channel modulator in epilepsy and neuropathic pain

Introduction Gabapentin is an antiepileptic drug and one of the most widely prescribed medications for neuropathic pain, postherpetic … Read more

Mechanism of Action of Ethosuximide

June 3, 2025 by Harsh Singh Rajput
Ethosuximide MOA – T-type calcium channel blocker for absence seizures

Introduction Ethosuximide is the first-line drug for treating absence seizures, a type of generalized seizure common in children. … Read more

Mechanism of Action of Topiramate

June 3, 2025 by Harsh Singh Rajput
Topiramate MOA – GABA enhancer, AMPA blocker, sodium channel inhibitor

Introduction Topiramate is a broad-spectrum antiepileptic drug (AED) known for its use in treating partial and generalized seizures, … Read more

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