Piperacetazine hydrochloride MCQs With Answer

Piperacetazine hydrochloride MCQs With Answer is a focused study resource tailored for B. Pharm students preparing for pharmacology, pharmaceutical chemistry, and quality control exams. This introduction covers pharmacological class, mechanism, formulation, stability, analytical testing, and common adverse effects of piperacetazine hydrochloride in concise, exam-oriented language. The MCQs emphasize practical aspects such as synthesis insights, assay methods, impurity profiling, dosage forms, drug interactions, and patient counseling points to deepen understanding beyond basic facts. Clear, keyword-rich questions help improve recall and application for coursework and competitive tests. Now let’s test your knowledge with 50 MCQs on this topic.

Q1. Which pharmacological class does piperacetazine hydrochloride primarily belong to?

• Typical antipsychotic (phenothiazine derivative)
• Selective serotonin reuptake inhibitor
• Benzodiazepine sedative
• Monoamine oxidase inhibitor

Correct Answer: Typical antipsychotic (phenothiazine derivative)

Q2. What is the primary mechanism of action of piperacetazine hydrochloride?

• Dopamine D2 receptor antagonism
• Serotonin 5-HT1A agonism
• GABA-A receptor modulation
• NMDA receptor antagonism

Correct Answer: Dopamine D2 receptor antagonism

Q3. Which formulation is most commonly used for piperacetazine hydrochloride in clinical practice?

• Oral tablets
• Inhalation powder
• Topical cream
• Transdermal patch

Correct Answer: Oral tablets

Q4. The hydrochloride salt of piperacetazine is used mainly to:

• Improve aqueous solubility and stability
• Increase lipid solubility for brain penetration
• Make the drug volatile for inhalation
• Convert it into a prodrug

Correct Answer: Improve aqueous solubility and stability

Q5. Which adverse effect is most characteristic of typical phenothiazine antipsychotics like piperacetazine?

• Extrapyramidal symptoms (EPS)
• Severe hyperglycemia only
• Renal tubular acidosis
• Thyroid storm

Correct Answer: Extrapyramidal symptoms (EPS)

Q6. Which laboratory parameter is commonly monitored if a patient is on long-term piperacetazine therapy?

• Liver function tests (LFTs)
• Serum amylase only
• Urine ketones daily
• Serum magnesium exclusively

Correct Answer: Liver function tests (LFTs)

Q7. Which drug interaction is most relevant for piperacetazine hydrochloride?

• Enhanced CNS depression with benzodiazepines
• Increased anticoagulant effect with vitamin C
• Chelation with magnesium supplements
• Antagonism by topical corticosteroids

Correct Answer: Enhanced CNS depression with benzodiazepines

Q8. Which adverse cardiovascular effect should be watched for with piperacetazine?

• Orthostatic hypotension
• Isolated bradyarrhythmia only during exercise
• Acute pericarditis
• Hypertrophic cardiomyopathy

Correct Answer: Orthostatic hypotension

Q9. Which of the following is a common anticholinergic side effect of piperacetazine?

• Dry mouth
• Severe hypoglycemia
• Increased salivation
• Excessive lacrimation

Correct Answer: Dry mouth

Q10. Which analytical technique is widely used for the assay of piperacetazine in bulk drug and formulations?

• High-performance liquid chromatography (HPLC)
• Flame photometry
• Turbidimetry
• Colorimetry for iron

Correct Answer: High-performance liquid chromatography (HPLC)

Q11. Which stability concern is commonly associated with phenothiazine derivatives like piperacetazine?

• Oxidation and photosensitivity
• Spontaneous polymerization at room temperature
• Explosive decomposition on exposure to air
• Complete stability under UV light

Correct Answer: Oxidation and photosensitivity

Q12. In formulation development, which excipient property is most important for tableting piperacetazine hydrochloride?

• Good flow and compressibility
• High hygroscopicity to retain moisture
• Strong oxidizing properties
• Magnetic susceptibility

Correct Answer: Good flow and compressibility

Q13. Which impurity profile is prioritized during quality control of piperacetazine hydrochloride?

• Related substances and degradation products
• Only heavy metal content above 500 ppm
• Microbial count for sterile injectables only
• Radioactive contaminants exclusively

Correct Answer: Related substances and degradation products

Q14. Which synthetic step is typically involved in producing piperazine-substituted phenothiazines?

• Alkylation of the phenothiazine nucleus with a piperazine side chain
• Direct nitration of the piperazine ring without protection
• Electroplating of phenothiazine onto metal
• Free radical polymerization of phenothiazine monomers

Correct Answer: Alkylation of the phenothiazine nucleus with a piperazine side chain

Q15. Which patient counseling point is important when starting piperacetazine?

• Avoid driving until you know how the drug affects you
• Increase sun exposure without protection
• Stop the drug abruptly if EPS occurs
• Double the dose if symptoms persist after one day

Correct Answer: Avoid driving until you know how the drug affects you

Q16. Which of the following is a typical sign of acute dystonia from piperacetazine?

• Sudden neck muscle contractions
• Gradual weight gain over months
• Intermittent hematuria
• Progressive hearing loss

Correct Answer: Sudden neck muscle contractions

Q17. Which pharmacokinetic process is primarily responsible for termination of piperacetazine action?

• Hepatic metabolism
• Renal filtration without metabolism
• Exhalation unchanged via lungs
• Evaporation from skin surface

Correct Answer: Hepatic metabolism

Q18. Which storage condition is recommended to minimize degradation of piperacetazine hydrochloride?

• Store in a cool, dark place in airtight container
• Expose to direct sunlight for stability
• Store at high humidity to prevent drying
• Keep at temperatures above 40°C

Correct Answer: Store in a cool, dark place in airtight container

Q19. Which regulatory test is essential for a batch release of piperacetazine tablets?

• Assay for active content and dissolution test
• Radioactivity screening only
• Ultrasound imaging of each tablet
• Chromatography for DNA content

Correct Answer: Assay for active content and dissolution test

Q20. Which adverse endocrine effect may occur with long-term use of typical antipsychotics?

• Hyperprolactinemia
• Hypocalcemia only during first week
• Persistent hypothyroidism within 24 hours
• Acute adrenal hyperfunction daily

Correct Answer: Hyperprolactinemia

Q21. Which photometric property can be used for preliminary identification of piperacetazine?

• UV absorption spectrum characteristic of aromatic systems
• Emits green fluorescence under normal light
• Shows no UV absorption at all
• Has a unique infrared band at 5000 cm-1

Correct Answer: UV absorption spectrum characteristic of aromatic systems

Q22. For impurity profiling, which technique complements HPLC for structural information?

• Mass spectrometry (MS)
• Colorimetry for calcium
• Simple refractometry
• Handheld metal detector

Correct Answer: Mass spectrometry (MS)

Q23. Which adverse effect is suggestive of tardive dyskinesia from chronic therapy?

• Involuntary repetitive movements of face and tongue
• Acute urinary retention after first dose
• Transient macular degeneration
• Intermittent epistaxis only during sleep

Correct Answer: Involuntary repetitive movements of face and tongue

Q24. Which dosing consideration is important for elderly patients on piperacetazine?

• Start at lower doses and titrate slowly
• Always use the highest recommended dose initially
• Avoid dose adjustments regardless of sensitivity
• Permit self-adjustment based on mood

Correct Answer: Start at lower doses and titrate slowly

Q25. Which manufacturing parameter is critical to ensure uniform drug content in tablets?

• Adequate mixing (blend uniformity)
• Rapid cooling below 0°C
• Exposure to UV during compression
• Elimination of all lubricants

Correct Answer: Adequate mixing (blend uniformity)

Q26. Which class of receptor blockade contributes to orthostatic hypotension with piperacetazine?

• Alpha-1 adrenergic receptor antagonism
• Beta-2 adrenergic receptor agonism
• M1 muscarinic receptor activation
• GABA-B receptor recruitment

Correct Answer: Alpha-1 adrenergic receptor antagonism

Q27. Which analytical parameter defines tablet performance for immediate-release piperacetazine tablets?

• Dissolution profile in appropriate medium
• Color uniformity under infrared only
• Electrical conductivity of the tablet
• Magnetic susceptibility of excipients

Correct Answer: Dissolution profile in appropriate medium

Q28. Which stability-indicating test is necessary to detect degradation of piperacetazine?

• Forced degradation studies followed by HPLC
• Simple melting point without chromatography
• Only organoleptic testing (smell/taste)
• Counting tablets under microscope

Correct Answer: Forced degradation studies followed by HPLC

Q29. Which patient history detail is most relevant before prescribing piperacetazine?

• History of Parkinson’s disease or movement disorders
• History of seasonal allergies only
• Preference for spicy foods
• Family history of color blindness

Correct Answer: History of Parkinson’s disease or movement disorders

Q30. What is a common management option for acute extrapyramidal reactions caused by piperacetazine?

• Administration of anticholinergic agents (e.g., benztropine)
• Immediate increase in piperacetazine dose
• Long-term anticoagulation
• Topical antibiotic therapy

Correct Answer: Administration of anticholinergic agents (e.g., benztropine)

Q31. Which quality attribute is assessed by hardness and friability tests for tablets?

• Mechanical strength and resistance to abrasion
• Chemical potency only
• Colorfastness to sunlight
• Magnetic resonance frequency

Correct Answer: Mechanical strength and resistance to abrasion

Q32. Which adverse metabolic effect may occur with some antipsychotics and requires monitoring?

• Weight gain and metabolic syndrome
• Immediate renal failure within hours
• Instantaneous bone density increase
• Permanent hair growth acceleration

Correct Answer: Weight gain and metabolic syndrome

Q33. Which solvent class is commonly used in HPLC methods for piperacetazine assay?

• Mixtures of water (buffer) and organic solvent such as acetonitrile or methanol
• Pure hexane only
• Nitrobenzene exclusively
• Gaseous methane as mobile phase

Correct Answer: Mixtures of water (buffer) and organic solvent such as acetonitrile or methanol

Q34. Which risk should be considered when combining piperacetazine with other dopamine antagonists?

• Increased risk of extrapyramidal symptoms
• Guaranteed prevention of EPS
• Mutual inactivation rendering both drugs useless
• Spontaneous resolution of psychiatric symptoms

Correct Answer: Increased risk of extrapyramidal symptoms

Q35. Which dosage form modification can reduce initial sedation caused by piperacetazine?

• Using lower starting dose and bedtime dosing
• Switching to an inhaled formulation
• Mixing with stimulant medications routinely
• Applying as topical ointment on the skin

Correct Answer: Using lower starting dose and bedtime dosing

Q36. Which regulatory document typically specifies the limits for related impurities in piperacetazine?

• Pharmacopoeial monograph (e.g., BP, USP, IP)
• Local newspaper advertisement
• Manufacturing company’s lunch menu
• Weather forecast bulletin

Correct Answer: Pharmacopoeial monograph (e.g., BP, USP, IP)

Q37. Which test helps confirm the identity of piperacetazine in raw material?

• Comparison of IR/UV spectra with reference standard
• Measuring pH of a 0.1% solution only
• Tasting a small amount for bitterness
• Painting it onto paper and checking color

Correct Answer: Comparison of IR/UV spectra with reference standard

Q38. Which precaution is advised regarding abrupt discontinuation of piperacetazine?

• Abrupt stoppage may precipitate withdrawal or symptom relapse; taper under supervision
• Immediate cessation is always recommended without consultation
• Doubling the dose for two days then stopping is preferred
• Switching to over-the-counter antihistamines is sufficient

Correct Answer: Abrupt stoppage may precipitate withdrawal or symptom relapse; taper under supervision

Q39. Which manufacturing impurity source must be controlled during synthesis of piperacetazine?

• Unreacted starting materials and side products from alkylation
• Extraneous pollen from the packaging room only
• Incorporation of active vitamin supplements
• Radioactive isotopes from water supply

Correct Answer: Unreacted starting materials and side products from alkylation

Q40. Which counseling point is relevant for photosensitivity risk with piperacetazine?

• Use sun protection and avoid prolonged sun exposure
• Intentionally increase sun exposure for therapeutic benefit
• Photosensitivity is not a concern with this class
• Only artificial infrared lamps are safe without protection

Correct Answer: Use sun protection and avoid prolonged sun exposure

Q41. Which adverse hematologic effect is occasionally associated with phenothiazines?

• Agranulocytosis (rare but serious)
• Immediate polycythemia within minutes
• Megaloblastic anemia in one pill
• Excessive thrombocyte proliferation daily

Correct Answer: Agranulocytosis (rare but serious)

Q42. Which characteristic of piperazine side chains influences CNS penetration?

• Basicity and lipophilicity affecting blood-brain barrier crossing
• Presence of halogens only in peripheral tissues
• Magnetism of nitrogen atoms overriding polarity
• pH-independent insolubility in body fluids

Correct Answer: Basicity and lipophilicity affecting blood-brain barrier crossing

Q43. Which risk factor increases susceptibility to orthostatic hypotension with piperacetazine?

• Concurrent antihypertensive therapy
• Use of topical emollients
• Wearing tight clothing
• High altitude sleeping

Correct Answer: Concurrent antihypertensive therapy

Q44. Which manufacturing control minimizes oxidative degradation during tableting?

• Use of antioxidants in formulation and exclusion of oxygen during processing
• Prolonged exposure to warm humid air
• Deliberate addition of peroxides
• Crushing tablets after compression

Correct Answer: Use of antioxidants in formulation and exclusion of oxygen during processing

Q45. Which statement about therapeutic drug monitoring of piperacetazine is true?

• Routine plasma-level monitoring is uncommon; clinical response guides dosing
• Plasma levels must be checked every hour in all patients
• Urine output directly correlates with efficacy
• Serum cholesterol measures drug concentration

Correct Answer: Routine plasma-level monitoring is uncommon; clinical response guides dosing

Q46. Which excipient class helps improve tablet disintegration for immediate release?

• Superdisintegrants (e.g., croscarmellose sodium)
• Hydrophobic lubricants only
• Permanent plasticizers that prevent water uptake
• Heavy metals to increase density

Correct Answer: Superdisintegrants (e.g., croscarmellose sodium)

Q47. Which monitoring is critical during initiation of piperacetazine to detect neuroleptic malignant syndrome (NMS)?

• Temperature and muscle rigidity assessment
• Daily ophthalmic fundus photography
• Routine EEG for all patients
• Serial liver biopsies

Correct Answer: Temperature and muscle rigidity assessment

Q48. Which feature distinguishes typical from atypical antipsychotics relevant to piperacetazine?

• Higher propensity for extrapyramidal symptoms with typical agents
• Complete absence of sedation in typical agents
• Typical agents only act on serotonin receptors
• Typical agents cure psychosis after one dose

Correct Answer: Higher propensity for extrapyramidal symptoms with typical agents

Q49. Which compatibility issue must formulator check when developing a combined tablet with piperacetazine?

• Chemical interaction between piperacetazine and co-formulated actives/excipients
• Whether piperacetazine will change tablet color to blue under all conditions
• Guaranteed synergistic evaporation with other drugs
• Automatic sterilization of the blend when mixed

Correct Answer: Chemical interaction between piperacetazine and co-formulated actives/excipients

Q50. Which documentation is most important for traceability and quality compliance of piperacetazine batches?

• Batch manufacturing record (BMR) and batch packaging record (BPR)
• Employee dietary logs
• Local bus timetable
• Customer satisfaction tweets only

Correct Answer: Batch manufacturing record (BMR) and batch packaging record (BPR)

G S Sachin

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.

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