MCQ Solubility of Drugs, States of Matter Physical Pharmaceutics, B.Pharm 3rd semester

MCQ Solubility of Drugs.

Multiple Choice Questions Of Solubility of Drugs, physical pharmaceutics,, 3rd semester.

1. The general strategies for increasing the aqueous solubility of a relatively non-polar drug of weak ionization tendency includes…….

  • (a) Increasing polarity of the solvent by the addition of cosolvents.
  • (b) Increasing ionization of the drug by adjusting the pH of the solvent.
  • (c) Choosing the amorphous form of the drug.
  • (d) (b) and (c) only

Answer-(d) (b) and (c) only

2. When non-polar substances are dissolved in a polar solvent using surfactants, the process is called

  • (a) HLB
  • (b)-Solubilisation
  • (c) Emulsification
  • (d) Gelatinization


4. Solubility of most gases usually …… with an increase in temperature.

  • (a) decreases
  • (b) increases
  • (d) first increases and then decreases
  • (c) does not change

Answer-(a) decreases

6. The ability of a substance to dissolve in a given solvent system depends on …….

  • (a) nature and intensity of the forces present in the solute
  •  (c) interactions between solute and solvent
  • (d) all the above

Answer-(a) nature and intensity of the forces present in the solute

8. The solubility of weak electrolytes and non-polar substances can be increased by adding water-miscible solvents. This process is known as ……

  • (a) Co-solvency
  • (b) Complexation
  • (c) Both of these
  • (d) None of these

Answer-(a) Co-solvency

9. How do co-solvents increase the solubility of poorly soluble drugs?

  • (a) By reducing the interfacial tension between the predominant aqueous solution and hydrophobic solute.
  •  (c) Both of these
  • (d) None of these

Answer-(a) By reducing the interfacial tension between the predominant aqueous solution and hydrophobic solute.

10. Which of the following co-solvents are used to increase the solubility of a drug?

  • (a) Ethanol
  • (c) Glycerin
  • (b) Sorbitol
  • (d) All the above

Answer-(d) All the above

Multiple Choice Questions of States of matter, physical pharmaceutics,, 3rd semester.

2. The phenomenon in which a substance exists in more than one crystalline form is called

  • (a) Polymorphism
  • (b) Crystallinity
  • (c) Anisotropy
  • (d) Polycrystallinity

Answer-(a) Polymorphism

3. Amorphous form dissolves crystalline form.

  • (a) slower than
  • (b) faster than
  • (c) at the same rate as
  • (d) Does not dissolve

Answer-(b) faster than

4. Mesomorphic substances are ……

  • (a) in between solid and liquid
  • (b) Nematic
  • (c) Smectic
  • (d) have different properties in different directions.

Answer-(a) in between solid and liquid

5. What kind of liquid crystals consist of parallel molecules in layers?

  • (a) Cholesteric
  • (b) Nematic
  • (c)-Smectic
  • (d) All of the above


6. The change of state from solid to directly into gas is known as ……

  • (a) Fusion
  • (b) Boiling
  • (c) Sublimation
  • (d) Evaporation

Answer-(c) Sublimation

7. The critical point of a pure substance is ……

  • (a) the highest temperature and pressure for which liquid and vapor can coexist.
  • (b) the point at which saturated liquid and saturated vapor curves meet.
  • (c) the point where vapor pressure has its largest possible value.
  • (d) all of the above

Answer-(d) all of the above

8. Which of the following properties are not shared by crystalline solids and amorphous solids?

  • (a) Definite shape
  • (b) Definite volume
  • (c) Incompressibility
  • (d) Definite melting point

Answer-(d) Definite melting point

9. Ratio of the velocity of light in a vacuum to the velocity of light in substance at same wavelength called as

  • (a) Refractive index
  • (b) Optical rotation
  • (c) Dipole moment
  • (d) None of these

Answer-(a) Refractive index

10. The ability of a substance to rotate the plane-polarized light is referred to as

  • (a) Refractivity
  • (b)-Optical activity
  • (c) Dielectric constant
  • (d) Dipole moment

Answer-(b)-Optical activity

11. Due to increase in temperature refractive index ……

  • (a) increases
  • (b) decreases
  • (c) remains unchanged
  • (d) depends on substance

Answer-(b) decreases

12. Oscillometry method is used to determine…….

  • (a) Refractive index
  • (b) Dielectric constant
  • (c) Dissociation constant
  • (d) Optical rotation

Answer-(b) Dielectric constant

13. When the analyzer is oriented into the polarizer, no light reaches the detector.

  • (a) 90°
  • (b) 45°
  • (c) 180°
  • (d) 0°

Answer-(a) 90°

14. Name a process through which a chemical compound breaks up into smaller constituents as a result of either energy or by the effect of solvent on a dissolved polar compound.

  • (a) Dissociation
  • (b) Association 
  • (c) Breaking
  •  (d) Desorption

Answer-(a) Dissociation

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