MCQ Quiz: Blood

Blood, the river of life, is a critical area of study for B.Pharm students. Understanding its composition, from plasma proteins to the various formed elements, and its vital functions like transport, immunity, and hemostasis, is essential. This knowledge forms the bedrock for learning about hematological drugs, transfusion medicine, and the pharmacokinetic profile of countless therapeutic agents. This quiz will test your core knowledge on this fundamental topic.


  1. Which of the following is the fluid matrix of blood?
    • Serum
    • Lymph
    • Plasma
    • Cytosol
    Answer: Plasma
  2. The process of blood cell formation is called:
    • Hemostasis
    • Hemolysis
    • Hemopoiesis
    • Hematocrit
    Answer: Hemopoiesis
  3. Which of these is NOT a formed element found in blood?
    • Erythrocytes
    • Leukocytes
    • Albumin
    • Thrombocytes
    Answer: Albumin
  4. The main function of red blood cells (erythrocytes) is to:
    • Fight infection
    • Transport oxygen
    • Clot blood
    • Maintain osmotic pressure
    Answer: Transport oxygen
  5. Which protein in red blood cells binds to and transports oxygen?
    • Fibrinogen
    • Hemoglobin
    • Globulin
    • Albumin
    Answer: Hemoglobin
  6. A condition characterized by a deficiency of red blood cells or hemoglobin is known as:
    • Leukemia
    • Anemia
    • Polycythemia
    • Thrombosis
    Answer: Anemia
  7. What is the most abundant type of white blood cell (leukocyte)?
    • Lymphocyte
    • Monocyte
    • Eosinophil
    • Neutrophil
    Answer: Neutrophil
  8. The final step in the coagulation cascade is the conversion of fibrinogen to what substance?
    • Thrombin
    • Prothrombin
    • Fibrin
    • Plasmin
    Answer: Fibrin
  9. A person with blood type A has which antigen on their red blood cells?
    • B antigen
    • A antigen
    • Rh antigen
    • No antigens
    Answer: A antigen
  10. Platelets are cell fragments derived from large cells called:
    • Erythroblasts
    • Myeloblasts
    • Megakaryocytes
    • Monoblasts
    Answer: Megakaryocytes
  11. Which plasma protein is most important for maintaining the osmotic pressure of the blood?
    • Globulins
    • Fibrinogen
    • Albumin
    • Prothrombin
    Answer: Albumin
  12. What is the primary function of leukocytes?
    • Oxygen transport
    • Defense against pathogens
    • Hemostasis
    • Nutrient transport
    Answer: Defense against pathogens
  13. If a person has blood type B, which antibodies are present in their plasma?
    • Anti-B antibodies
    • Anti-A antibodies
    • Both Anti-A and Anti-B antibodies
    • No antibodies
    Answer: Anti-A antibodies
  14. The term for the stoppage of bleeding is:
    • Hemopoiesis
    • Agglutination
    • Hemostasis
    • Hemolysis
    Answer: Hemostasis
  15. The Rh factor is an antigen found on the surface of:
    • White blood cells
    • Platelets
    • Red blood cells
    • Plasma proteins
    Answer: Red blood cells
  16. Which leukocytes differentiate into macrophages in body tissues?
    • Neutrophils
    • Eosinophils
    • Lymphocytes
    • Monocytes
    Answer: Monocytes
  17. Formation of a platelet plug is a key step in:
    • The immune response
    • Oxygen delivery
    • Hemostasis
    • Hemopoiesis
    Answer: Hemostasis
  18. A person with AB blood type is considered the “universal recipient” because they lack:
    • A and B antigens
    • Anti-A and Anti-B antibodies
    • Rh factor
    • H antigen
    Answer: Anti-A and Anti-B antibodies
  19. The clumping of red blood cells due to an antigen-antibody reaction is called:
    • Coagulation
    • Agglutination
    • Fibrinolysis
    • Hemolysis
    Answer: Agglutination
  20. Which mineral is essential for the synthesis of hemoglobin?
    • Calcium
    • Sodium
    • Iron
    • Potassium
    Answer: Iron
  21. Which leukocytes release histamine and are involved in inflammatory and allergic responses?
    • Basophils
    • Eosinophils
    • Neutrophils
    • Lymphocytes
    Answer: Basophils
  22. The liquid portion of blood from which clotting factors have been removed is called:
    • Plasma
    • Serum
    • Interstitial fluid
    • Lymph
    Answer: Serum
  23. Which of the following is an agranulocyte?
    • Neutrophil
    • Eosinophil
    • Basophil
    • Lymphocyte
    Answer: Lymphocyte
  24. The percentage of total blood volume occupied by red blood cells is the:
    • Hemoglobin count
    • Hematocrit
    • Differential count
    • Platelet count
    Answer: Hematocrit
  25. The primary site of hemopoiesis in adults is the:
    • Liver
    • Spleen
    • Yellow bone marrow
    • Red bone marrow
    Answer: Red bone marrow
  26. Which of the following is a key activator in the common pathway of coagulation?
    • Prothrombin activator
    • Plasmin
    • Heparin
    • Vitamin K
    Answer: Prothrombin activator
  27. A person with type O blood is considered the “universal donor” because their red blood cells lack:
    • A and B antigens
    • Anti-A and Anti-B antibodies
    • The Rh antigen
    • A nucleus
    Answer: A and B antigens
  28. Which leukocytes are phagocytic and are the “first responders” to bacterial infections?
    • Monocytes
    • Lymphocytes
    • Neutrophils
    • Basophils
    Answer: Neutrophils
  29. Hemolytic disease of the newborn can occur when an Rh-negative mother has a second child who is:
    • Rh-negative
    • Rh-positive
    • Blood type A
    • Blood type O
    Answer: Rh-positive
  30. What is the function of platelets?
    • To transport gases
    • To produce antibodies
    • To form a plug and aid in blood clotting
    • To phagocytize bacteria
    Answer: To form a plug and aid in blood clotting
  31. Which plasma proteins include antibodies (immunoglobulins)?
    • Albumins
    • Globulins
    • Fibrinogens
    • Metalloproteins
    Answer: Globulins
  32. A stationary blood clot formed inside a vessel is a(n):
    • Embolus
    • Thrombus
    • Plaque
    • Agglutinin
    Answer: Thrombus
  33. Which leukocytes are associated with combating parasitic worm infections?
    • Basophils
    • Monocytes
    • Neutrophils
    • Eosinophils
    Answer: Eosinophils
  34. The average lifespan of a healthy red blood cell is approximately:
    • 24 hours
    • 30 days
    • 120 days
    • 1 year
    Answer: 120 days
  35. The term describing a lower-than-normal number of platelets is:
    • Thrombocytosis
    • Thrombocytopenia
    • Leukopenia
    • Anemia
    Answer: Thrombocytopenia
  36. All blood cells originate from a single type of cell called a:
    • Megakaryocyte
    • Reticulocyte
    • Hemocytoblast (hematopoietic stem cell)
    • Proerythroblast
    Answer: Hemocytoblast (hematopoietic stem cell)
  37. The Reticuloendothelial System is a network of phagocytic cells primarily found in the:
    • Brain and spinal cord
    • Skeletal muscles
    • Spleen, liver, and lymph nodes
    • Heart and blood vessels
    Answer: Spleen, liver, and lymph nodes
  38. Which of the following is required for the proper synthesis of clotting factors in the liver?
    • Vitamin C
    • Vitamin K
    • Vitamin B12
    • Vitamin D
    Answer: Vitamin K
  39. The rupture of red blood cells is called:
    • Crenation
    • Hemolysis
    • Agglutination
    • Hemostasis
    Answer: Hemolysis
  40. Which two leukocytes are the main players in adaptive immunity?
    • Neutrophils and Monocytes
    • Eosinophils and Basophils
    • T-lymphocytes and B-lymphocytes
    • Macrophages and Neutrophils
    Answer: T-lymphocytes and B-lymphocytes
  41. A mismatch during blood transfusion causes a severe reaction primarily due to:
    • Recipient antibodies reacting with donor antigens
    • Recipient antigens reacting with donor antibodies
    • Coagulation factors being activated
    • An allergic reaction to plasma proteins
    Answer: Recipient antibodies reacting with donor antigens
  42. A moving blood clot, air bubble, or fat globule in the bloodstream is a(n):
    • Thrombus
    • Embolus
    • Plaque
    • Hematoma
    Answer: Embolus
  43. Which organ is primarily responsible for removing old and damaged red blood cells from circulation?
    • Kidney
    • Liver
    • Spleen
    • Gallbladder
    Answer: Spleen
  44. The biconcave shape of an erythrocyte serves to:
    • Carry more hemoglobin
    • Increase the surface area-to-volume ratio for gas exchange
    • Help the cell squeeze through narrow capillaries
    • Both B and C are correct
    Answer: Both B and C are correct
  45. What percentage of whole blood is made up of formed elements?
    • 10%
    • 25%
    • 45%
    • 55%
    Answer: 45%
  46. Which of these is NOT a granular leukocyte?
    • Eosinophil
    • Basophil
    • Monocyte
    • Neutrophil
    Answer: Monocyte
  47. When hemoglobin is broken down, the heme portion is converted into:
    • Amino acids
    • Iron and biliverdin
    • Globin
    • Fibrin
    Answer: Iron and biliverdin
  48. An individual who is B-positive (B+) has which antigens on their RBCs?
    • B antigen only
    • B and Rh antigens
    • A and Rh antigens
    • Rh antigen only
    Answer: B and Rh antigens
  49. The immediate response to blood vessel injury is:
    • Coagulation
    • Fibrinolysis
    • Vascular spasm
    • Platelet repulsion
    Answer: Vascular spasm
  50. Which component makes up the smallest percentage of whole blood?
    • PlasmaRed blood cellsWhite blood cells and plateletsWater
    Answer: White blood cells and platelets

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