1. What is the clinical definition of leukopenia in an adult?
2. Agranulocytosis, a life-threatening condition, is characterized by an Absolute Neutrophil Count (ANC) below:
3. Which of the following drugs is classically associated with idiosyncratic drug-induced agranulocytosis?
4. A patient undergoing chemotherapy for breast cancer develops neutropenia. What is the primary underlying mechanism?
5. Felty’s syndrome is a clinical triad consisting of rheumatoid arthritis, splenomegaly, and which other finding?
6. Leukocytosis is defined as a total white blood cell count exceeding:
7. Which laboratory finding is most useful in differentiating a leukemoid reaction from Chronic Myeloid Leukemia (CML)?
8. A peripheral blood smear from a patient with a severe bacterial infection shows neutrophilia. Which other morphologic changes are expected?
9. A young adult with fever, pharyngitis, and lymphadenopathy has a blood smear showing a high percentage of large, atypical lymphocytes (Downey cells). What is the most likely causative agent?
10. Which bacterial infection classically causes a marked absolute lymphocytosis, particularly in unimmunized children?
11. A markedly elevated eosinophil count (eosinophilia) is most commonly associated with which category of conditions?
12. A patient with recurrent oral ulcers and infections every 21 days has fluctuating neutrophil counts on serial CBCs. What is the most probable diagnosis?
13. Which of the following conditions is a well-recognized cause of chronic monocytosis?
14. A significantly elevated basophil count (basophilia) on a CBC is most strongly suggestive of which of the following conditions?
15. The administration of corticosteroids can cause a transient neutrophilia primarily through which mechanism?
16. The term “left shift” in a differential white blood cell count refers to an increase in the number of:
17. Which of the following is a common cause of lymphopenia (lymphocytopenia)?
18. The atypical lymphocytes seen in infectious mononucleosis are predominantly activated:
19. A leukoerythroblastic reaction, characterized by immature granulocytes and nucleated RBCs in peripheral blood, suggests:
20. A patient with chemotherapy-induced febrile neutropenia (ANC < 500/μL) might be treated with which agent to stimulate neutrophil production?
21. Kostmann syndrome, a severe congenital neutropenia, is most commonly caused by mutations in which gene?
22. How does massive splenomegaly typically contribute to leukopenia?
23. Eosinophilia is defined as an absolute eosinophil count (AEC) greater than:
24. Which cytokine plays a central role in stimulating the bone marrow to produce and release neutrophils during acute bacterial infections?
25. Which of the following is the most common cause of acquired neutropenia in clinical practice?
