Etidocaine MCQs With Answer

Etidocaine MCQs With Answer is a focused review for B. Pharm students covering etidocaine’s pharmacology, clinical uses, pharmacokinetics, adverse effects, and safe administration. This concise guide emphasizes key topics: etidocaine as an amide local anesthetic, mechanism of action (voltage‑gated sodium channel blockade), onset and duration, metabolism, interactions with vasoconstrictors, toxicity management, and practical considerations in regional and epidural anesthesia. Questions are designed to reinforce understanding of structure–activity relationships, monitoring for systemic toxicity, and comparisons with other local anesthetics. Ideal for exam prep and clinical application, the MCQs promote deeper learning beyond superficial facts. Now let’s test your knowledge with 30 MCQs on this topic.

Q1. Which class of local anesthetic does etidocaine belong to?

• Amide local anesthetic
• Ester local anesthetic
• Opioid analgesic
• Ketone anesthetic

Correct Answer: Amide local anesthetic

Q2. What is the primary mechanism of action of etidocaine?

• Activation of GABA receptors
• Blockade of voltage‑gated sodium channels
• Inhibition of cyclooxygenase enzymes
• Agonism at opioid receptors

Correct Answer: Blockade of voltage‑gated sodium channels

Q3. The major route of metabolism for etidocaine is:

• Plasma esterases hydrolysis
• Hepatic metabolism
• Renal tubular secretion unchanged
• Pulmonary exhalation

Correct Answer: Hepatic metabolism

Q4. How are etidocaine metabolites primarily eliminated from the body?

• Fecal excretion via bile
• Renal excretion of metabolites
• Exhalation through the lungs
• Skin sebum secretion

Correct Answer: Renal excretion of metabolites

Q5. Compared with lidocaine, etidocaine is generally:

• Less potent and shorter acting
• More potent and longer acting
• Identical in potency and duration
• Only used topically

Correct Answer: More potent and longer acting

Q6. In comparison to bupivacaine, etidocaine is particularly known for causing:

• Greater sensory selectivity with minimal motor block
• Pronounced motor blockade
• Higher risk of allergic reactions
• No cardiovascular effects

Correct Answer: Pronounced motor blockade

Q7. Co‑administration of epinephrine with etidocaine typically results in:

• Faster metabolism and shorter duration
• Prolonged duration and reduced systemic absorption
• Increased systemic toxicity immediately
• Complete blockade of local action

Correct Answer: Prolonged duration and reduced systemic absorption

Q8. Which clinical applications are common for etidocaine?

• Infiltration, peripheral nerve block, and epidural anesthesia
• General intravenous anesthesia induction
• Long‑term oral analgesia
• Topical antifungal therapy

Correct Answer: Infiltration, peripheral nerve block, and epidural anesthesia

Q9. The earliest signs of systemic toxicity from etidocaine often involve the:

• Gastrointestinal tract (nausea and vomiting)
• Central nervous system (tinnitus, dizziness, seizures)
• Renal system (oliguria)
• Skin (rash only)

Correct Answer: Central nervous system (tinnitus, dizziness, seizures)

Q10. Allergic reactions to etidocaine are relatively uncommon because it is an:

• Amide local anesthetic
• Ester local anesthetic
• Synthetic opioid
• Corticosteroid derivative

Correct Answer: Amide local anesthetic

Q11. Which property most strongly correlates with the potency of etidocaine?

• Water solubility
• Lipid solubility
• Color of the solution
• pH of the formulation only

Correct Answer: Lipid solubility

Q12. Which pharmacokinetic factor most influences the onset of action of etidocaine?

• Protein binding
• pKa relative to physiological pH
• Renal clearance rate
• Chirality of the molecule

Correct Answer: pKa relative to physiological pH

Q13. What factor mainly determines the duration of action of etidocaine?

• Degree of protein binding
• Color of the ampoule
• Plasma glucose concentration
• Route of excretion through lungs

Correct Answer: Degree of protein binding

Q14. In treating severe local anesthetic systemic toxicity (LAST) from etidocaine, the recommended specific therapy includes:

• Intravenous lipid emulsion therapy
• High‑dose corticosteroids
• Oral activated charcoal
• Topical cooling

Correct Answer: Intravenous lipid emulsion therapy

Q15. Which patient condition requires extra caution or dose adjustment when using etidocaine?

• Severe hepatic impairment
• Well‑controlled seasonal allergies
• Mild, treated hypothyroidism
• Uncomplicated fracture of bone

Correct Answer: Severe hepatic impairment

Q16. Compared to smaller sensory fibers, motor fibers are typically:

• Less susceptible to blockade by etidocaine
• More susceptible to blockade by etidocaine
• Unaffected by local anesthetics
• Only blocked by opioids

Correct Answer: More susceptible to blockade by etidocaine

Q17. Which monitoring is most important immediately after epidural injection of etidocaine?

• Blood glucose only
• Cardiovascular and respiratory status
• Daily weight measurements
• Skin pH monitoring

Correct Answer: Cardiovascular and respiratory status

Q18. Why are amide local anesthetics like etidocaine less likely to produce allergic reactions than ester types?

• They do not penetrate nerve membranes
• They are metabolized by plasma esterases more rapidly
• They lack para‑aminobenzoic acid (PABA) metabolites associated with allergy
• They permanently bind to plasma proteins

Correct Answer: They lack para‑aminobenzoic acid (PABA) metabolites associated with allergy

Q19. Which technique reduces the risk of intravascular injection when administering etidocaine?

• Aspirating before injection and incremental dosing
• Injecting full dose rapidly without aspiration
• Using topical application only
• Administering via inhalation

Correct Answer: Aspirating before injection and incremental dosing

Q20. A characteristic clinical advantage of adding epinephrine to etidocaine is:

• It increases systemic toxicity by rapid uptake
• It reduces local blood flow to prolong anesthesia
• It converts etidocaine into an ester anesthetic
• It neutralizes etidocaine’s action completely

Correct Answer: It reduces local blood flow to prolong anesthesia

Q21. Which sign is indicative of early cardiovascular toxicity from etidocaine overdose?

• Hypertension and bradycardia only
• Hypotension and arrhythmias
• Hyperreflexia without other symptoms
• Isolated rash at injection site

Correct Answer: Hypotension and arrhythmias

Q22. Combining multiple amide local anesthetics (including etidocaine) increases the risk of:

• Reduced anesthetic efficacy but no toxicity
• Enhanced systemic toxicity due to additive effects
• Specific immunity to local anesthetics
• Immediate renal failure always

Correct Answer: Enhanced systemic toxicity due to additive effects

Q23. Which physical property of etidocaine contributes to its ability to penetrate nerve membranes?

• High molecular weight only
• Lipid solubility
• Metal ion content
• Optical rotation

Correct Answer: Lipid solubility

Q24. Regarding obstetric use, etidocaine is generally used with caution because it can cause:

• Excessive maternal motor block potentially affecting labor
• Complete fetal immunity to pain
• Guaranteed prevention of postpartum hemorrhage
• No transfer across the placenta

Correct Answer: Excessive maternal motor block potentially affecting labor

Q25. The most appropriate immediate step if signs of CNS excitation (tremors, seizures) appear after etidocaine injection is:

• Administer benzodiazepines and supportive care
• Give large oral doses of acetaminophen
• Ignore symptoms and continue injection
• Apply topical local anesthetic to the scalp

Correct Answer: Administer benzodiazepines and supportive care

Q26. Etidocaine formulations are commonly supplied as:

• Hydrochloride salts with or without epinephrine
• Alcoholic tinctures for oral use
• Intravenous emulsions only for general anesthesia
• Sublingual tablets for chronic pain

Correct Answer: Hydrochloride salts with or without epinephrine

Q27. The order of nerve fiber blockade by etidocaine typically favors blocking which fibers first?

• Large myelinated motor fibers first
• Small myelinated pain fibers and autonomic fibers first
• Only unmyelinated fibers without affecting others
• All fibers simultaneously without selectivity

Correct Answer: Small myelinated pain fibers and autonomic fibers first

Q28. Which patient history element is most relevant to consider before choosing etidocaine?

• History of severe hepatic disease
• History of seasonal allergic rhinitis only
• Past fractures of long bones unrelated to anesthesia
• Recent vaccination status

Correct Answer: History of severe hepatic disease

Q29. Which statement about systemic absorption of etidocaine is true?

• Systemic absorption is greatest after epidural injection compared with intravenous injection
• Addition of vasoconstrictors decreases systemic absorption from the injection site
• Systemic absorption cannot be influenced by technique or additives
• Renal function solely determines systemic absorption

Correct Answer: Addition of vasoconstrictors decreases systemic absorption from the injection site

Q30. For exam preparation and clinical application, mastering etidocaine requires understanding of:

• Pharmacodynamics, pharmacokinetics, toxicity management, and clinical uses
• Only its chemical synthesis steps
• How to use it as a systemic analgesic for chronic pain exclusively
• That it is interchangeable with oral NSAIDs in every case

Correct Answer: Pharmacodynamics, pharmacokinetics, toxicity management, and clinical uses

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