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Harsh Singh Rajput

I am pursuing MBA in pharmaceutical management from NIPER Hyderabad with a strong academic record and proven success in national-level pharmacy entrance exams. I secured AIR 61 in NIPER 2024 (MS/M.Pharm) and AIR 27 in NIPER MBA, along with AIR 147 in GPAT 2024 and AIR 907 in GPAT 2023. I also achieved AIR 6 in AIIMS CRE-2025 for Drug Store Keeper and was selected as a Pharmacist (AIR 61) for ESIC. Additionally, I was the Runner-Up in Round 2 of the EY Case Study Competition. At PharmacyFreak.com, I aim to guide future pharmacists through expert content, exam strategies, and insightful resources based on real experience and academic excellence. Mail- harsh@pharmacyfreak.com

Mechanism of Action of Linezolid (Oxazolidinone Antibiotics)

June 23, 2025June 22, 2025 by Harsh Singh Rajput
Linezolid MOA – 50S ribosomal subunit and initiation inhibition

Introduction Linezolid is a synthetic bacteriostatic antibiotic belonging to the oxazolidinone class. It is primarily active against Gram-positive … Read more

Mechanism of Action of Sulfonamides (Folic Acid Synthesis Inhibitors)

June 23, 2025June 21, 2025 by Harsh Singh Rajput
Sulfonamide MOA – Folic acid synthesis inhibition via dihydropteroate synthase

Introduction Sulfonamides are synthetic bacteriostatic antibiotics that inhibit folic acid synthesis in bacteria. Because mammals obtain folate from … Read more

Mechanism of Action of Glycopeptides (e.g., Vancomycin)

June 23, 2025June 21, 2025 by Harsh Singh Rajput
Vancomycin MOA – D-Ala-D-Ala binding and peptidoglycan inhibition

Introduction Glycopeptides, most notably vancomycin, are a class of bactericidal antibiotics that inhibit bacterial cell wall synthesis by … Read more

Mechanism of Action of Tetracyclines (Broad-Spectrum 30S Ribosome Inhibitors)

June 23, 2025June 21, 2025 by Harsh Singh Rajput
Tetracycline MOA – 30S ribosome binding and tRNA blocking

Introduction Tetracyclines are a class of broad-spectrum bacteriostatic antibiotics that inhibit bacterial protein synthesis. Common examples include tetracycline, … Read more

Mechanism of Action of Aminoglycosides

July 4, 2025June 20, 2025 by Harsh Singh Rajput
Aminoglycoside MOA – 30S ribosomal subunit binding and mRNA misreading

Introduction Aminoglycosides are potent bactericidal antibiotics used mainly against aerobic Gram-negative bacilli and serious systemic infections. Common examples … Read more

Mechanism of Action of Fluoroquinolones (DNA Gyrase and Topoisomerase Inhibitors)

July 4, 2025June 20, 2025 by Harsh Singh Rajput
Fluoroquinolone MOA – Inhibition of DNA gyrase and topoisomerase

Introduction Fluoroquinolones are a powerful class of bactericidal antibiotics that inhibit bacterial DNA replication. They are widely used … Read more

Mechanism of Action of Macrolides (Protein Synthesis Inhibitor Antibiotics)

June 23, 2025June 20, 2025 by Harsh Singh Rajput
Macrolide MOA – 50S ribosome binding and protein synthesis inhibition

Introduction Macrolides are a widely used class of bacteriostatic antibiotics that inhibit bacterial protein synthesis. They are especially … Read more

Mechanism of Action of Cephalosporins (β-Lactam Antibiotics)

June 23, 2025June 19, 2025 by Harsh Singh Rajput
Cephalosporin MOA – PBP inhibition and bacterial cell wall lysis

Introduction Cephalosporins are a large group of β-lactam antibiotics, structurally and functionally similar to penicillins. They are classified … Read more

Mechanism of Action of Penicillins (β-lactam Antibiotics)

June 23, 2025June 19, 2025 by Harsh Singh Rajput
Penicillins MOA – Cell wall synthesis inhibition

Introduction Penicillins are one of the oldest and most widely used classes of antibiotics, belonging to the β-lactam … Read more

Mechanism of Action of Lacosamide (Newer Antiepileptic Drug)

June 23, 2025June 18, 2025 by Harsh Singh Rajput
Lacosamide MOA – Enhances slow inactivation of sodium channels in epilepsy

Introduction Lacosamide is a newer-generation antiepileptic drug (AED) used for the treatment of focal (partial) seizures and adjunctive … Read more

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