Adsorption method MCQs With Answer
Adsorption is a key physicochemical process in pharmaceutics that governs drug stability, formulation, purification, and toxicology. This comprehensive set of MCQs for B. Pharm students explores adsorption principles, adsorption isotherms (Langmuir, Freundlich, BET), adsorption kinetics and thermodynamics, adsorbents (activated charcoal, silica gel, ion-exchange resins), surface area and pore-size effects, column and batch adsorption, regeneration and breakthrough curves, and practical pharmaceutical applications such as taste masking, drug purification, and chromatographic separations. Questions emphasize interpretation of isotherm parameters, adsorption capacity units, rate-limiting steps, and real-world formulation implications. Now let’s test your knowledge with 30 MCQs on this topic.
Q1. What is adsorption?
- Accumulation of molecules at the surface of a solid or liquid
- Penetration of molecules into the bulk of a solid
- Formation of a covalent bond with the adsorbent
- Conversion of a gas to a solution
Correct Answer: Accumulation of molecules at the surface of a solid or liquid
Q2. Which thermodynamic nature is most commonly associated with physical adsorption?
- Endothermic process involving bond formation
- Exothermic process due to van der Waals interactions
- Isothermal and entropy-driven
- Always irreversible and highly specific
Correct Answer: Exothermic process due to van der Waals interactions
Q3. Which assumption is central to the Langmuir adsorption isotherm?
- Multilayer adsorption on a heterogeneous surface
- Monolayer adsorption on a homogeneous surface with identical binding sites
- Adsorption capacity increases indefinitely with concentration
- Adsorption energy increases with surface coverage
Correct Answer: Monolayer adsorption on a homogeneous surface with identical binding sites
Q4. The Freundlich isotherm is best described as which of the following?
- A theoretical model assuming uniform adsorption energy
- An empirical model for adsorption on heterogeneous surfaces
- A model that predicts monolayer capacity explicitly
- A model applicable only to gas-phase adsorption
Correct Answer: An empirical model for adsorption on heterogeneous surfaces
Q5. The BET method is primarily used to determine which property of an adsorbent?
- Chemical reactivity with adsorbates
- Specific surface area via multilayer adsorption measurements
- Ion-exchange capacity
- Thermal stability of adsorbent
Correct Answer: Specific surface area via multilayer adsorption measurements
Q6. In pharmacy, activated charcoal is widely used because it has:
- High solubility in gastric fluid
- High surface area and strong non-specific adsorption of toxins
- Selective covalent binding to drugs
- Ion-exchange properties for salts
Correct Answer: High surface area and strong non-specific adsorption of toxins
Q7. Which kinetic model is commonly interpreted as indicating chemisorption?
- Pseudo-first-order (Lagergren) model
- Pseudo-second-order kinetic model
- Zero-order kinetic model
- Freundlich kinetic model
Correct Answer: Pseudo-second-order kinetic model
Q8. Typical units for adsorption capacity in batch studies are given as:
- mol·L
- mg·g⁻¹ (milligrams of adsorbate per gram of adsorbent)
- J·mol⁻¹
- m²·g⁻¹
Correct Answer: mg·g⁻¹ (milligrams of adsorbate per gram of adsorbent)
Q9. A breakthrough curve in a fixed-bed adsorption column plots:
- Adsorbent surface area versus time
- Effluent concentration (C/C0) or concentration versus time or volume of effluent
- Temperature of the bed versus time
- Adsorbent pore size distribution
Correct Answer: Effluent concentration (C/C0) or concentration versus time or volume of effluent
Q10. How does increasing temperature generally affect physical adsorption from a gas or liquid?
- It increases adsorption due to higher diffusion
- It decreases adsorption because physical adsorption is exothermic
- It has no effect on adsorption equilibria
- It always converts physical adsorption into chemisorption
Correct Answer: It decreases adsorption because physical adsorption is exothermic
Q11. Which factor most directly increases adsorption capacity of a porous adsorbent?
- Lower surface area
- Higher surface area and optimal pore volume
- Reduced pore volume
- Decrease in adsorbent particle size without changing surface area
Correct Answer: Higher surface area and optimal pore volume
Q12. For a spontaneous adsorption process at constant temperature and pressure, the sign of Gibbs free energy change (ΔG) is typically:
- Positive
- Zero
- Negative
- Undefined
Correct Answer: Negative
Q13. Which adsorbent is commonly preferred for moisture adsorption in pharmaceutical packaging?
- Activated charcoal
- Silica gel
- Ion-exchange resin
- Polystyrene foam
Correct Answer: Silica gel
Q14. Ion-exchange resins are most suitable for which pharmaceutical application?
- Adsorption of nonpolar organic vapors
- Removal or separation of ionic drugs and counter-ions
- Taste masking of neutral molecules by van der Waals forces
- Thermal reactivation of activated charcoal
Correct Answer: Removal or separation of ionic drugs and counter-ions
Q15. When adsorption exhibits a long tail and slow approach to equilibrium, the likely rate-limiting step is:
- External film diffusion only
- Intraparticle (pore) diffusion within adsorbent particles
- Instantaneous adsorption at the surface
- Chemical reaction producing the adsorbent
Correct Answer: Intraparticle (pore) diffusion within adsorbent particles
Q16. In the Freundlich isotherm, the constant 1/n represents:
- The monolayer adsorption capacity
- Adsorption intensity or surface heterogeneity; values <1 indicate favorable adsorption
- The adsorbent pore size
- The heat of adsorption per mole
Correct Answer: Adsorption intensity or surface heterogeneity; values <1 indicate favorable adsorption
Q17. In the Langmuir equation, the constant b is related to:
- The maximum multilayer capacity
- The equilibrium constant related to affinity between adsorbate and adsorbent
- The surface area exclusively
- The diffusion coefficient in solution
Correct Answer: The equilibrium constant related to affinity between adsorbate and adsorbent
Q18. The preferred industrial method to regenerate spent activated charcoal is:
- Simple rinsing with water
- Thermal reactivation at high temperature in controlled atmosphere
- Freezing to detach adsorbates
- Adding salts to precipitate adsorbates
Correct Answer: Thermal reactivation at high temperature in controlled atmosphere
Q19. Why does solution pH strongly influence adsorption of ionizable drugs?
- Because pH changes the temperature of the solution
- Because pH alters the ionization state of the drug and surface charge of the adsorbent
- Because pH increases adsorbent surface area
- Because pH converts physical adsorption into absorption
Correct Answer: Because pH alters the ionization state of the drug and surface charge of the adsorbent
Q20. An adsorption isotherm plots which variables?
- Amount adsorbed at equilibrium (q_e) versus equilibrium concentration (C_e)
- Temperature versus time
- Adsorbent mass vs particle size
- Pressure versus volume only for liquids
Correct Answer: Amount adsorbed at equilibrium (q_e) versus equilibrium concentration (C_e)
Q21. Which method is commonly used to analyze pore size distribution (mesopores) of an adsorbent?
- Langmuir isotherm analysis
- BJH (Barrett-Joyner-Halenda) method
- Freundlich exponent plot
- Lagergren kinetic plot
Correct Answer: BJH (Barrett-Joyner-Halenda) method
Q22. In the Langmuir model the parameter Qm represents:
- Multilayer adsorption capacity
- Monolayer adsorption capacity at saturation
- Diffusion coefficient of adsorbate
- Surface heterogeneity index
Correct Answer: Monolayer adsorption capacity at saturation
Q23. Which of the following is a characteristic of chemisorption?
- Weak van der Waals interactions only
- Formation of specific chemical bonds and often irreversibility
- Always reversible at room temperature
- Independent of surface chemical nature
Correct Answer: Formation of specific chemical bonds and often irreversibility
Q24. Which linearized form is commonly used to determine Langmuir constants from experimental data?
- Plot of q_e versus C_e directly without transformation
- Plot of 1/q_e versus 1/C_e (reciprocal linear form)
- Plot of log q_e versus log C_e
- Plot of q_e² versus C_e
Correct Answer: Plot of 1/q_e versus 1/C_e (reciprocal linear form)
Q25. Which chromatographic technique primarily depends on adsorption interactions with the stationary phase?
- Size-exclusion chromatography
- Normal-phase (silica) adsorption chromatography
- Ion-exchange chromatography (relies on ionic interactions only)
- Gas chromatography with nonpolar stationary phase only
Correct Answer: Normal-phase (silica) adsorption chromatography
Q26. The Lagergren equation describes which adsorption kinetic order?
- Pseudo-first-order kinetics
- Pseudo-zero-order kinetics
- Pseudo-second-order kinetics
- Michaelis-Menten kinetics
Correct Answer: Pseudo-first-order kinetics
Q27. In competitive adsorption from solution, preferential adsorption of one component is mainly determined by:
- The molecular weight alone
- The relative affinity constants and interaction energies with the adsorbent surface
- The color of the adsorbate
- The viscosity of the solvent only
Correct Answer: The relative affinity constants and interaction energies with the adsorbent surface
Q28. Adsorption typically causes the system entropy (ΔS) to:
- Increase greatly due to ordering at the surface
- Decrease because adsorbate molecules become more ordered on the surface
- Remain unchanged always
- Become positive for all chemisorption processes
Correct Answer: Decrease because adsorbate molecules become more ordered on the surface
Q29. The Langmuir isotherm is most valid under which pressure/concentration conditions for gas adsorption?
- Very high pressures where multilayer formation dominates
- Relatively low pressures/concentrations where monolayer formation is the main process
- Only at the critical point of the gas
- When the adsorbent is chemically reacting with the gas
Correct Answer: Relatively low pressures/concentrations where monolayer formation is the main process
Q30. Which pair of adsorbent properties most strongly controls adsorption capacity for organic drugs?
- Color and melting point of the adsorbent
- Surface area and pore volume/size distribution
- Thermal conductivity and electrical resistivity
- Bulk density alone
Correct Answer: Surface area and pore volume/size distribution

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