Buclizine hydrochloride MCQs With Answer

Buclizine hydrochloride MCQs With Answer offers B.Pharm students a focused review of buclizine hydrochloride — an H₁ antihistamine with antiemetic and anticholinergic properties used in motion sickness and nausea. This concise, keyword-rich introduction covers mechanism of action, clinical indications, dosing, pharmacokinetics, adverse effects, contraindications, drug interactions, formulations, and pharmacy considerations. Designed to deepen understanding beyond basics, the questions emphasize therapeutic rationale, safety monitoring, and formulation knowledge relevant to pharmacy practice. Each MCQ reinforces core pharmacology and dispensing principles to prepare you for exams and practical pharmacy tasks. Now let’s test your knowledge with 30 MCQs on this topic.

Q1. What is the primary pharmacological classification of buclizine hydrochloride?

• Beta blocker
• H1 antihistamine with antiemetic properties
• Proton pump inhibitor
• Opioid analgesic

Correct Answer: H1 antihistamine with antiemetic properties

Q2. The primary mechanism by which buclizine reduces nausea is through antagonism of which receptor type?

• Dopamine D2 receptors
• Muscarinic M2 receptors
• Histamine H1 receptors
• 5-HT3 receptors

Correct Answer: Histamine H1 receptors

Q3. Which additional pharmacological action contributes to buclizine’s antiemetic effect?

• ACE inhibition
• Anticholinergic (antimuscarinic) activity
• Beta-2 agonism
• Alpha-1 blockade

Correct Answer: Anticholinergic (antimuscarinic) activity

Q4. For which clinical indication is buclizine most commonly prescribed?

• Hypertension
• Motion sickness and vertigo-associated nausea
• Chronic heart failure
• Bacterial infections

Correct Answer: Motion sickness and vertigo-associated nausea

Q5. Which adverse effect is most frequently associated with buclizine use?

• Hyperglycemia
• Excessive sedation and drowsiness
• Excessive diuresis
• Hypertensive crisis

Correct Answer: Excessive sedation and drowsiness

Q6. Buclizine should be used cautiously or avoided in patients with which condition?

• Open-angle glaucoma
• Narrow-angle glaucoma
• Type I diabetes mellitus
• Osteoporosis

Correct Answer: Narrow-angle glaucoma

Q7. Which drug interaction is a significant concern when buclizine is co-administered?

• Reduced effect of oral contraceptives
• Additive CNS depression with benzodiazepines and alcohol
• Antagonism with metformin
• Synergistic antihypertensive effect with ACE inhibitors

Correct Answer: Additive CNS depression with benzodiazepines and alcohol

Q8. What is a common anticholinergic side effect of buclizine?

• Bradycardia
• Hypersalivation
• Dry mouth and blurred vision
• Excessive sweating

Correct Answer: Dry mouth and blurred vision

Q9. Which patient population requires special caution when prescribing buclizine due to increased sensitivity to anticholinergic effects?

• Children under 2 years only
• Elderly patients
• Healthy young adults
• All athletes

Correct Answer: Elderly patients

Q10. The typical adult oral dose of buclizine commonly available in many formularies is closest to:

• 0.5 mg once daily
• 10–20 mg as needed
• 200 mg twice daily
• 500 mg once daily

Correct Answer: 10–20 mg as needed

Q11. Which pregnancy-related statement about buclizine is most appropriate for pharmacy counseling?

• It is proven absolutely safe in all trimesters
• Use in pregnancy should be based on risk–benefit assessment and clinician guidance
• It is a first-line treatment for hyperemesis gravidarum
• It is contraindicated in breastfeeding only

Correct Answer: Use in pregnancy should be based on risk–benefit assessment and clinician guidance

Q12. Buclizine’s onset of action and duration are most relevant to which counseling point for motion sickness prevention?

• Take immediately after symptoms start for instant relief
• Take prior to travel for optimal preventive effect
• Apply topically behind the ear
• Only effective when injected intramuscularly

Correct Answer: Take prior to travel for optimal preventive effect

Q13. Which laboratory monitoring is routinely required for patients on buclizine?

• Frequent liver function tests
• No routine laboratory monitoring is typically required
• Daily complete blood counts
• Serum potassium every week

Correct Answer: No routine laboratory monitoring is typically required

Q14. In terms of drug formulation knowledge, buclizine is commonly available as:

• Injectable depot suspension only
• Oral tablets and oral syrup formulations
• Transdermal patches exclusively
• Topical cream for local application

Correct Answer: Oral tablets and oral syrup formulations

Q15. Which contraindication is most applicable to buclizine therapy?

• Known hypersensitivity to buclizine or related antihistamines
• Mild seasonal rhinitis without symptoms
• History of controlled hyperlipidemia
• Well-managed hypothyroidism

Correct Answer: Known hypersensitivity to buclizine or related antihistamines

Q16. Which pharmacokinetic property should be emphasized when considering dosing frequency of buclizine?

• Extensive renal clearance with 2-hour half-life
• Oral bioavailability and relatively moderate duration allowing intermittent dosing
• Completely eliminated unchanged in feces
• Requires continuous IV infusion due to rapid clearance

Correct Answer: Oral bioavailability and relatively moderate duration allowing intermittent dosing

Q17. Which exam-focused point about buclizine chemical class is correct?

• It is a beta-lactam antibiotic
• It is an antihistamine related to piperazine derivatives
• It is a corticosteroid analogue
• It is a macrolide antibacterial

Correct Answer: It is an antihistamine related to piperazine derivatives

Q18. When counseling on storage and stability, what is the recommended advice for buclizine tablets?

• Store below 0°C and freeze for stability
• Keep in original container, away from excessive heat and moisture
• Store under direct sunlight to maintain potency
• Keep refrigerated at all times

Correct Answer: Keep in original container, away from excessive heat and moisture

Q19. Which adverse cardiovascular effect can occur with anticholinergic antihistamines like buclizine in overdose?

• Severe bradyarrhythmia only
• Tachycardia and palpitations
• Immediate myocardial infarction in all patients
• Marked hypotension unrelated to dose

Correct Answer: Tachycardia and palpitations

Q20. For compounding a pediatric syrup from buclizine tablets, which pharmacy consideration is essential?

• Assume equal potency without calculation
• Calculate correct dose per weight and ensure suitable vehicle and stability data
• Use saline as the only vehicle for taste-masking
• No need for labeling of beyond-use date

Correct Answer: Calculate correct dose per weight and ensure suitable vehicle and stability data

Q21. Which statement about buclizine and driving or operating machinery is appropriate?

• It enhances alertness and is safe for driving
• It may impair alertness; patients should avoid driving if drowsy
• It only impairs motor skills in the first 30 seconds
• There is no effect on psychomotor performance

Correct Answer: It may impair alertness; patients should avoid driving if drowsy

Q22. In case of buclizine overdose, which initial management step is most appropriate?

• Immediate dialysis as first-line
• Supportive care and symptomatic treatment, including monitoring vitals
• Administer high-dose benzodiazepine to reverse toxicity
• Give insulin infusion to counteract effects

Correct Answer: Supportive care and symptomatic treatment, including monitoring vitals

Q23. Which laboratory assay principle could be used to quantify buclizine in a formulation for quality control?

• Chromatographic methods such as HPLC
• Gram staining technique
• Hemagglutination assay
• Blood culture

Correct Answer: Chromatographic methods such as HPLC

Q24. Which effect would likely NOT be expected with buclizine therapy?

• Antiemetic relief in motion sickness
• Marked cholinergic stimulation like increased salivation
• Mild sedation
• Dry mouth

Correct Answer: Marked cholinergic stimulation like increased salivation

Q25. When teaching about drug interactions, buclizine combined with other anticholinergic drugs may cause:

• Reduced anticholinergic burden
• Additive anticholinergic toxicity leading to confusion and urinary retention
• Complete antagonism of buclizine effect
• Rapid enzymatic degradation of both drugs

Correct Answer: Additive anticholinergic toxicity leading to confusion and urinary retention

Q26. Which regulatory/labeling counseling point should be provided when dispensing buclizine to diabetic patients?

• No special counseling needed for diabetics
• Advise on monitoring for blurred vision which may be anticholinergic-related and to report glycemic changes
• Stop insulin when starting buclizine
• Double the sulfonylurea dose when taking buclizine

Correct Answer: Advise on monitoring for blurred vision which may be anticholinergic-related and to report glycemic changes

Q27. Which of the following best describes buclizine’s suitability for pediatric use?

• Never used in children under any circumstance
• Used with dose adjustment and pediatric formulation, following guidelines
• Always given at the adult dose regardless of weight
• Only administered by intravenous route in children

Correct Answer: Used with dose adjustment and pediatric formulation, following guidelines

Q28. From a stability and packaging viewpoint, which excipient property is important for an oral buclizine tablet formulation?

• High hygroscopicity to absorb moisture
• Moisture protection to prevent degradation
• Use of volatile solvents in final packaging
• Transparent packaging for UV exposure

Correct Answer: Moisture protection to prevent degradation

Q29. Which statement about buclizine metabolism and excretion is most accurate for exam-level understanding?

• Primarily excreted unchanged in sweat
• Metabolized hepatically with renal excretion of metabolites
• Excreted solely via the respiratory route
• Completely metabolized to glucose

Correct Answer: Metabolized hepatically with renal excretion of metabolites

Q30. Which counseling point about missed dose or as-needed use of buclizine is correct?

• If missed, take double dose next time
• Use as directed for prevention of motion sickness; do not exceed recommended dose
• Continue taking daily even if not traveling to build tolerance
• Stop all other medications when starting buclizine

Correct Answer: Use as directed for prevention of motion sickness; do not exceed recommended dose

G S Sachin

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.

Mail- Sachin@pharmacyfreak.com