Hypothyroidism MCQ Quiz | Endocrinology & Metabolism

Welcome to the Hypothyroidism MCQ Quiz, designed specifically for MBBS students to test and reinforce their understanding of this critical topic in Endocrinology. This quiz covers the etiology, pathophysiology, clinical manifestations, diagnosis, and management of hypothyroidism. You will encounter 25 multiple-choice questions that reflect the complexity and depth required for your curriculum. After completing the quiz, you can submit your answers to see your score, with immediate feedback highlighting the correct and incorrect responses. For your revision and future reference, there is an option to download a PDF document containing all the questions along with their correct answers. This is an excellent tool for self-assessment and exam preparation. Good luck!

1. A 45-year-old female presents with fatigue, weight gain, and cold intolerance. Her lab results show an elevated TSH and a low free T4. What is the most likely diagnosis?

2. What is the most common cause of primary hypothyroidism in iodine-sufficient regions of the world?

3. A patient diagnosed with Hashimoto’s thyroiditis is most likely to have high titers of which antibody?

4. A patient has low free T4 and inappropriately normal or low TSH levels. This pattern is suggestive of a defect at what level?

5. Which of the following is a classic clinical sign of severe, long-standing hypothyroidism?

6. What is the standard treatment for hypothyroidism?

7. A patient on a stable dose of levothyroxine becomes pregnant. What adjustment is typically required for her medication?

8. Myxedema coma is a life-threatening complication of hypothyroidism. Which of the following is NOT part of its classic presentation?

9. How is “subclinical hypothyroidism” biochemically defined?

10. Which medication is well-known to cause hypothyroidism through mechanisms including decreased synthesis and release of thyroid hormones?

11. A characteristic finding on physical examination of a hypothyroid patient’s deep tendon reflexes is:

12. Which lipid profile abnormality is commonly associated with hypothyroidism?

13. The best way to monitor the adequacy of levothyroxine replacement therapy in a patient with primary hypothyroidism is by measuring:

14. Congenital hypothyroidism, if left untreated, leads to:

15. A patient complains of a very hard, “stony” or “woody” thyroid gland that is fixed to adjacent structures. This presentation is characteristic of:

16. What is the Wolff-Chaikoff effect?

17. Histological examination of a thyroid gland affected by Hashimoto’s thyroiditis typically reveals:

18. A patient with hypothyroidism is instructed to take their levothyroxine. What is the best instruction to ensure optimal absorption?

19. Which cardiovascular finding is typically associated with hypothyroidism?

20. In the initial management of a patient in myxedema coma, in addition to IV levothyroxine, what other medication is crucial?

21. A patient with a goiter and sensorineural deafness likely has which syndrome?

22. Which hematological abnormality is most commonly seen in patients with hypothyroidism?

23. Tertiary hypothyroidism is caused by a deficiency of which hormone?

24. What ECG changes can be seen in a patient with severe hypothyroidism?

25. Which of the following conditions is associated with an atrophic, non-goitrous form of autoimmune thyroiditis?