Viral Hepatitis & Acute Liver Failure MCQ Quiz | Gastrointestinal

Welcome to this specialized quiz for MBBS students, focusing on Viral Hepatitis and Acute Liver Failure. This quiz is designed to test your understanding of key concepts in virology, serology, clinical presentation, and management of these critical gastrointestinal conditions. You will face 25 multiple-choice questions covering Hepatitis A, B, C, D, and E, as well as the pathophysiology and clinical criteria of acute liver failure. After submitting your answers, you’ll receive your score, with correct and incorrect answers highlighted for review. For your convenience and future study, you can download all the questions and their correct answers in a PDF format. Good luck!

1. A 25-year-old male presents with jaundice and fatigue after returning from a trip where he consumed contaminated water. Which mode of transmission is most likely responsible for his condition?

Parenteral

Fecal-oral

Sexual contact

Vertical transmission

2. Which serological marker profile is most indicative of an acute Hepatitis B virus (HBV) infection?

HBsAg (+), Anti-HBc IgG (+), Anti-HBs (-)

HBsAg (-), Anti-HBc IgG (+), Anti-HBs (+)

HBsAg (+), Anti-HBc IgM (+), Anti-HBs (-)

HBsAg (-), Anti-HBc IgG (-), Anti-HBs (+)

3. A medical student has completed their Hepatitis B vaccination series and their serology is checked. Which pattern confirms successful immunization?

Positive for Anti-HBs only

Positive for HBsAg only

Positive for Anti-HBc IgG only

Positive for both HBsAg and Anti-HBs

4. Which of the following hepatitis viruses is a DNA virus?

Hepatitis A virus

Hepatitis B virus

Hepatitis C virus

Hepatitis E virus

5. A patient with chronic Hepatitis B infection presents with a sudden, severe worsening of their liver function. This is likely due to a superinfection with which virus?

Hepatitis A virus

Hepatitis C virus

Hepatitis D virus

Hepatitis E virus

6. Which viral hepatitis has the highest rate of progression to chronic infection?

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis E

7. A 28-year-old pregnant woman in her third trimester develops fulminant hepatitis. Which virus is most infamously associated with high mortality in this population?

HAV

HBV

HCV

HEV

8. Which of the following is the most widely accepted definition of Acute Liver Failure (ALF)?

ALT > 1000 U/L and jaundice

Presence of ascites and peripheral edema

Coagulopathy (INR ≥1.5) and any degree of encephalopathy in a patient without pre-existing cirrhosis

Serum bilirubin > 10 mg/dL and presence of asterixis

9. In the United States and the UK, what is the most common cause of drug-induced acute liver failure?

Isoniazid

Paracetamol (Acetaminophen)

Halothane

Amiodarone

10. A patient is brought to the ER with paracetamol-induced ALF. What is the specific antidote that should be administered?

Naloxone

Flumazenil

N-acetylcysteine (NAC)

Methylene blue

11. The “window period” of an acute HBV infection is characterized by the presence of which sole serological marker?

HBsAg

Anti-HBs

Anti-HBc IgM

HBeAg

12. Which of the following is a well-known extrahepatic manifestation of chronic Hepatitis C infection?

Polyarteritis nodosa

Aplastic anemia

Mixed cryoglobulinemia

Gianotti-Crosti syndrome

13. A patient is screened for Hepatitis C and is found to be Anti-HCV positive. What is the next essential step to confirm active infection?

Repeat Anti-HCV test in 6 months

Check for HCV RNA by PCR

Perform a liver biopsy

Measure liver enzymes (ALT/AST)

14. According to King’s College Criteria for liver transplantation in non-paracetamol induced ALF, which of the following is an independent criterion?

Arterial pH < 7.30

Serum creatinine > 2.0 mg/dL

INR > 6.5

Age < 10 years

15. What is the primary mechanism of action of lactulose in the management of hepatic encephalopathy?

It kills urease-producing bacteria in the gut

It acts as a sedative to reduce brain activity

It acidifies the colon, converting ammonia (NH3) to non-absorbable ammonium (NH4+)

It directly binds ammonia in the bloodstream

16. The presence of which marker in a chronic HBV patient indicates a high level of viral replication and high infectivity?

HBsAg

Anti-HBc IgG

HBeAg

HBV DNA

17. A patient’s serology report shows Anti-HBs (+) and Anti-HBc IgG (+). HBsAg is negative. What is the correct interpretation?

Acute HBV infection

Chronic HBV infection

Immunity due to vaccination

Resolved past infection

18. Which of the following hepatitis viruses does NOT have a recognized chronic carrier state?

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

19. Which serological marker profile is consistent with a chronic Hepatitis B carrier who has low infectivity?

HBsAg (+), HBeAg (+), Anti-HBe (-)

HBsAg (+), HBeAg (-), Anti-HBe (+)

HBsAg (-), HBeAg (-), Anti-HBe (+)

HBsAg (+), HBeAg (+), Anti-HBe (+)

20. The complete, infectious Hepatitis B virion is also known as the:

Dane particle

Australia antigen

Core antigen

E-antigen

21. What is the most important single prognostic factor in a patient with acute liver failure?

Serum bilirubin level

Degree of coagulopathy (INR)

Grade of hepatic encephalopathy

Serum aminotransferase levels

22. Which form of post-exposure prophylaxis is recommended for an unvaccinated household contact of a patient with acute Hepatitis A?

Hepatitis B vaccine

Hepatitis A vaccine and/or immunoglobulin

A course of Ribavirin

No prophylaxis is needed

G S Sachin

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.

Mail- Sachin@pharmacyfreak.com

Viral Hepatitis & Acute Liver Failure MCQ Quiz | Gastrointestinal

Quiz Results