Typhoid Fever MCQ Quiz | Infectious Diseases

Welcome to the Typhoid Fever MCQ Quiz, designed for MBBS students. This quiz will test your understanding of the etiology, pathogenesis, clinical features, diagnosis, management, and prevention of enteric fever. Covering key concepts from *Salmonella enterica* serovar Typhi infection to its clinical implications, these 25 questions are curated to align with the infectious diseases curriculum. This assessment is an excellent tool for self-evaluation and revision before your professional exams. After submitting your answers, you will receive your score, and the correct answers will be highlighted for your review. For offline study, you can use the download button to get a PDF version of all the questions and their correct answers. Good luck!

1. What is the primary causative agent of typhoid fever?

2. The characteristic “step-ladder” fever pattern in typhoid is typically seen during which week of illness?

3. Faget’s sign, a clinical finding in typhoid fever, refers to:

4. The “rose spots” characteristic of typhoid fever are most commonly found on which part of the body?

5. What is the gold standard for diagnosis of typhoid fever in the first week of illness?

6. The primary site of multiplication of *S. Typhi* after ingestion is in the:

7. Which of the following is the most common and serious complication of typhoid fever, typically occurring in the third week?

8. A characteristic hematological finding in typhoid fever is:

9. The Widal test detects the presence of which antibodies in the patient’s serum?

10. The chronic carrier state in typhoid fever is most commonly associated with the persistence of bacteria in which organ?

11. Which of the following antibiotics is the drug of choice for treating multidrug-resistant (MDR) typhoid fever?

12. The live attenuated oral typhoid vaccine is known as:

13. Which diagnostic test for typhoid has the highest sensitivity, especially if blood cultures are negative?

14. The term “typhoid state” refers to a clinical condition characterized by:

15. The incubation period of typhoid fever is typically:

16. Which of these gastrointestinal symptoms is more common in the early stages (first week) of typhoid fever?

17. Histopathologically, typhoid nodules (or Fraenkel’s nodules) are composed primarily of aggregates of:

18. Relapse in typhoid fever, if it occurs, most commonly happens:

19. The Vi antigen of *S. Typhi* is a:

20. For which patient group is Azithromycin often considered a first-line treatment for uncomplicated typhoid fever?

21. The main mode of transmission for typhoid fever is:

22. Which of the following is NOT a feature of *Salmonella Typhi*?

23. In the management of severe typhoid fever, corticosteroids are indicated primarily to:

24. What is the main limitation of the Widal test?

25. Eradication of the chronic carrier state of *S. Typhi* may sometimes require which surgical procedure in addition to prolonged antibiotic therapy?