Triflupromazine MCQs With Answer

Triflupromazine MCQs With Answer is a focused review resource for B.Pharm students preparing pharmacology exams. This introduction and question set cover triflupromazine’s pharmacology, mechanism of action as a phenothiazine antipsychotic, therapeutic indications, dosing, pharmacokinetics, metabolism, adverse effects such as extrapyramidal symptoms, anticholinergic effects, hypotension, QT prolongation, and serious reactions like neuroleptic malignant syndrome. Emphasis on drug interactions, monitoring parameters, and contraindications, and patient counseling helps strengthen clinical decision-making. Each MCQ includes clear explanations to reinforce learning and exam readiness. Targeted keywords like triflupromazine, antipsychotic pharmacology, B.Pharm, and MCQs are integrated for SEO relevance. Now let’s test your knowledge with 50 MCQs on this topic.

Q1. What is the primary mechanism of action of triflupromazine?

• Selective serotonin reuptake inhibition
• Potent D2 receptor antagonism in dopaminergic pathways
• GABA-A receptor potentiation
• NMDA receptor antagonism

Correct Answer: Potent D2 receptor antagonism in dopaminergic pathways

Q2. Triflupromazine belongs to which class of antipsychotic drugs?

• Benzodiazepines
• Phenothiazines
• Butyrophenones
• Atypical antipsychotics

Correct Answer: Phenothiazines

Q3. A common early adverse effect of triflupromazine related to dopamine blockade is:

• Hyperprolactinemia
• Extrapyramidal symptoms (acute dystonia, akathisia)
• Weight loss
• Hypoglycemia

Correct Answer: Extrapyramidal symptoms (acute dystonia, akathisia)

Q4. Which serious but rare syndrome is associated with antipsychotics including triflupromazine?

• Serotonin syndrome
• Neuroleptic malignant syndrome (NMS)
• Stevens-Johnson syndrome
• Carcinoid syndrome

Correct Answer: Neuroleptic malignant syndrome (NMS)

Q5. Which cardiovascular effect should be monitored when prescribing triflupromazine?

• Bradyarrhythmia due to beta-blockade
• QT interval prolongation and risk of torsades de pointes
• Myocardial ischemia from coronary vasospasm
• Endocarditis risk

Correct Answer: QT interval prolongation and risk of torsades de pointes

Q6. Which of the following is a common anticholinergic side effect of triflupromazine?

• Diarrhea
• Urinary retention and dry mouth
• Hyperreflexia
• Excessive salivation

Correct Answer: Urinary retention and dry mouth

Q7. Triflupromazine can increase levels of which hormone due to dopamine blockade?

• Insulin
• Prolactin
• Cortisol
• Thyroxine

Correct Answer: Prolactin

Q8. Which patient condition is a relative contraindication to starting triflupromazine?

• History of controlled asthma
• Parkinson’s disease due to worsened motor symptoms
• Well-controlled hypertension
• Mild seasonal allergies

Correct Answer: Parkinson’s disease due to worsened motor symptoms

Q9. The hepatic handling of triflupromazine is best described as:

• Excreted unchanged in urine
• Extensively metabolized in the liver (hepatic metabolism)
• Eliminated via bile unchanged only
• Not metabolized and stored in fat indefinitely

Correct Answer: Extensively metabolized in the liver (hepatic metabolism)

Q10. Which laboratory test is most appropriate to monitor before and during therapy if clinically indicated for triflupromazine?

• Fasting blood glucose only
• Electrocardiogram (ECG) for QT interval and baseline liver function tests
• Skin prick allergy testing
• Routine urine culture

Correct Answer: Electrocardiogram (ECG) for QT interval and baseline liver function tests

Q11. Triflupromazine’s sedative effect is primarily due to blockade of which receptor?

• H1 histamine receptors
• Beta-2 adrenergic receptors
• 5-HT3 serotonin receptors
• NMDA receptors

Correct Answer: H1 histamine receptors

Q12. Which drug interaction is important to avoid with triflupromazine because it increases CNS depression?

• Selective serotonin reuptake inhibitors (SSRIs)
• Benzodiazepines or alcohol
• Oral contraceptives
• Topical antifungals

Correct Answer: Benzodiazepines or alcohol

Q13. What type of extrapyramidal symptom is characterized by sustained involuntary muscle contractions causing abnormal postures?

• Tardive dyskinesia
• Acute dystonia
• Akathisia
• Pseudobulbar affect

Correct Answer: Acute dystonia

Q14. Long-term use of triflupromazine can lead to which late-onset movement disorder?

• Restless legs syndrome
• Tardive dyskinesia
• Bells palsy
• Myasthenia gravis

Correct Answer: Tardive dyskinesia

Q15. A B.Pharm student studying triflupromazine should advise that antipsychotic-induced orthostatic hypotension is mainly due to blockade of:

• Muscarinic receptors
• Alpha-1 adrenergic receptors
• Beta-1 adrenergic receptors
• Dopamine D4 receptors

Correct Answer: Alpha-1 adrenergic receptors

Q16. Which symptom is an early sign of neuroleptic malignant syndrome to watch for with triflupromazine?

• Severe muscle rigidity and high fever
• Mild rash on the trunk
• Isolated blurred vision
• Gradual weight gain

Correct Answer: Severe muscle rigidity and high fever

Q17. Triflupromazine’s antiemetic effect is primarily due to antagonism at which site?

• 5-HT1A receptors in the gut
• Dopamine receptors in the chemoreceptor trigger zone (CTZ)
• Muscarinic receptors in the vomiting center
• Ghrelin receptors

Correct Answer: Dopamine receptors in the chemoreceptor trigger zone (CTZ)

Q18. Which population requires dose adjustment and careful monitoring when using triflupromazine?

• Elderly patients due to increased sensitivity and orthostatic hypotension
• Young healthy adults with no comorbidities
• Professional athletes only
• Those with short-term insomnia

Correct Answer: Elderly patients due to increased sensitivity and orthostatic hypotension

Q19. Which neurotransmitter imbalance is most directly targeted by triflupromazine in psychosis?

• Excess glutamate activity in cortex
• Excess dopaminergic transmission in mesolimbic pathway
• Low GABAergic tone in limbic system
• Excess cholinergic signaling in basal ganglia

Correct Answer: Excess dopaminergic transmission in mesolimbic pathway

Q20. Which adverse effect indicates anticholinergic toxicity from triflupromazine overdose?

• Diaphoresis and miosis
• Dry mouth, hyperthermia, urinary retention
• Hypersalivation and bradycardia
• Profuse lacrimation and diarrhea

Correct Answer: Dry mouth, hyperthermia, urinary retention

Q21. Which is the most appropriate immediate management for acute dystonic reaction caused by triflupromazine?

• Start an SSRI
• Give an anticholinergic injection like benztropine or procyclidine
• Administer high-dose benzodiazepines only
• Increase the dose of triflupromazine

Correct Answer: Give an anticholinergic injection like benztropine or procyclidine

Q22. Interaction between triflupromazine and drugs that prolong QT interval can increase risk of:

• Hyperkalemia
• Torsades de pointes
• Renal failure
• Hypoglycemia

Correct Answer: Torsades de pointes

Q23. Which hepatic enzyme family commonly metabolizes many phenothiazines including triflupromazine?

• CYP450 enzymes
• Monoamine oxidase (MAO)
• Peptidyl transferase
• Glutathione synthetase

Correct Answer: CYP450 enzymes

Q24. Which monitoring is important when triflupromazine is used long-term because of metabolic risks?

• Regular pulmonary function tests
• Periodic assessment of weight, glucose and lipid profile
• Frequent audiometry
• Routine ophthalmic intraocular pressure checks weekly

Correct Answer: Periodic assessment of weight, glucose and lipid profile

Q25. Triflupromazine’s antipsychotic potency compared to haloperidol is generally:

• More potent than haloperidol
• Approximately similar in potency to haloperidol
• Less potent than many high-potency typical antipsychotics
• Not an antipsychotic at all

Correct Answer: Less potent than many high-potency typical antipsychotics

Q26. A patient on triflupromazine reports involuntary repetitive facial movements after months of therapy. This is most consistent with:

• Akathisia
• Tardive dyskinesia
• Acute dystonia
• Parkinsonism unrelated to drug

Correct Answer: Tardive dyskinesia

Q27. Which adverse effect would suggest dose reduction or discontinuation of triflupromazine?

• Mild transient headache
• Marked orthostatic hypotension and syncope
• Occasional yawning
• Temporary mild thirst

Correct Answer: Marked orthostatic hypotension and syncope

Q28. Co-administration of triflupromazine with drugs that inhibit CYP450 may cause:

• Decreased plasma levels and reduced effect
• Increased plasma concentrations and risk of toxicity
• No interaction at all
• Immediate allergic reaction always

Correct Answer: Increased plasma concentrations and risk of toxicity

Q29. Which sign suggests hyperprolactinemia in a patient on triflupromazine?

• Polydipsia
• Galactorrhea and menstrual disturbances
• Excessive sweating at night
• Brisk reflexes

Correct Answer: Galactorrhea and menstrual disturbances

Q30. For acute severe agitation due to psychosis, triflupromazine may be given via which route for rapid effect?

• Topical application
• Intramuscular injection
• Transdermal patch
• Inhalation

Correct Answer: Intramuscular injection

Q31. Which precaution is advised when prescribing triflupromazine to a patient with epilepsy?

• It lowers seizure threshold and requires caution
• It prevents seizures and is protective
• No special precautions are needed
• It cures epilepsy after long-term use

Correct Answer: It lowers seizure threshold and requires caution

Q32. In terms of receptor profile, triflupromazine has significant blockade at which receptor that contributes to sexual dysfunction and hyperprolactinemia?

• GABA-B receptor
• Dopamine D2 receptor
• Alpha-2 adrenergic receptor
• 5-HT1A receptor

Correct Answer: Dopamine D2 receptor

Q33. Which symptom cluster differentiates akathisia from other EPS?

• Severe rigidity and tremor
• Inner restlessness and inability to sit still
• Rhythmic chewing movements only
• Sudden eye deviation

Correct Answer: Inner restlessness and inability to sit still

Q34. If a patient on triflupromazine develops fever, rigidity, autonomic instability and altered mental status, the pharmacist should advise immediate:

• Increase in dose and oral hydration
• Emergency medical evaluation for neuroleptic malignant syndrome
• Use of topical analgesic
• Gradual dose taper at home

Correct Answer: Emergency medical evaluation for neuroleptic malignant syndrome

Q35. Triflupromazine use during labour is associated with which consideration?

• It is absolutely contraindicated in all cases
• May cause neonatal extrapyramidal symptoms and requires risk-benefit assessment
• Always recommended to accelerate labour
• Prevents postpartum hemorrhage

Correct Answer: May cause neonatal extrapyramidal symptoms and requires risk-benefit assessment

Q36. Which adverse effect is least likely with triflupromazine compared to atypical antipsychotics?

• Weight gain and metabolic syndrome
• Extrapyramidal symptoms
• Akathisia
• Acute dystonia

Correct Answer: Weight gain and metabolic syndrome

Q37. Which patient counseling point is important when dispensing triflupromazine tablets?

• It can be stopped abruptly at any time without effects
• Avoid alcohol and be cautious when standing to prevent dizziness
• No caution required for driving or operating machinery
• Sun exposure is completely safe without sunscreen

Correct Answer: Avoid alcohol and be cautious when standing to prevent dizziness

Q38. Which adverse hepatic effect can be associated with phenothiazines like triflupromazine?

• Cholestatic or hepatocellular liver injury
• Immediate renal tubular necrosis
• Autoimmune hepatitis exclusively
• Pancreatic necrosis

Correct Answer: Cholestatic or hepatocellular liver injury

Q39. Which is a correct pharmacokinetic consideration for oral triflupromazine?

• Has negligible oral absorption
• Undergoes first-pass hepatic metabolism affecting bioavailability
• Is eliminated primarily unchanged in breath
• Is fully bioavailable and not metabolized

Correct Answer: Undergoes first-pass hepatic metabolism affecting bioavailability

Q40. Combining triflupromazine with anticholinergic medications may lead to:

• Reduced anticholinergic effects overall
• Exacerbation of anticholinergic side effects and toxicity
• Guaranteed prevention of EPS with no risks
• Complete reversal of triflupromazine action

Correct Answer: Exacerbation of anticholinergic side effects and toxicity

Q41. For a B.Pharm student, which pharmacodynamic concept explains both antipsychotic benefit and EPS with triflupromazine?

• Noncompetitive agonism at NMDA receptors
• Dopamine D2 receptor antagonism in different brain regions
• Peripheral blockade of beta receptors only
• Inhibition of acetylcholinesterase in CNS

Correct Answer: Dopamine D2 receptor antagonism in different brain regions

Q42. Which clinical sign is more characteristic of drug-induced parkinsonism from triflupromazine?

• Marked hyperactivity
• Bradykinesia, rigidity and resting tremor
• Isolated severe headache only
• Sudden loss of vision

Correct Answer: Bradykinesia, rigidity and resting tremor

Q43. Which medication class can be used to reduce severe akathisia in a patient on triflupromazine?

• Beta-blockers like propranolol
• Systemic corticosteroids
• Fluoroquinolone antibiotics
• Strong CYP inducers

Correct Answer: Beta-blockers like propranolol

Q44. Which clinical monitoring is specifically relevant early after starting triflupromazine?

• Serial ECGs, blood pressure checks and observation for EPS
• Only annual dental exam
• Routine bone density scanning weekly
• Daily liver biopsy

Correct Answer: Serial ECGs, blood pressure checks and observation for EPS

Q45. When counseling about missed doses of oral triflupromazine, advise the patient to:

• Double the next dose immediately
• Take the missed dose as soon as remembered, but do not double doses
• Stop therapy permanently
• Mix tablets with other antipsychotics without advice

Correct Answer: Take the missed dose as soon as remembered, but do not double doses

Q46. Which adverse effect merits urgent discontinuation of triflupromazine and specialist review?

• Mild transient drowsiness
• Agranulocytosis or severe unexplained infection
• Minor constipation that resolves
• Temporary mild sexual dysfunction

Correct Answer: Agranulocytosis or severe unexplained infection

Q47. Which of the following best describes the role of a B.Pharm graduate regarding triflupromazine therapy?

• Prescribe and initiate therapy independently without supervision
• Provide medication counseling, check interactions, and advise monitoring to support safe use
• Ignore side effects as they are not relevant to pharmacists
• Discourage all antipsychotic therapy regardless of diagnosis

Correct Answer: Provide medication counseling, check interactions, and advise monitoring to support safe use

Q48. In the case of severe QT prolongation suspected with triflupromazine, the immediate action should be:

• Continue therapy and reassess in a month
• Stop the drug and arrange urgent cardiac evaluation
• Prescribe another QT-prolonging drug
• Increase the dose to overcome side effects

Correct Answer: Stop the drug and arrange urgent cardiac evaluation

Q49. Which statement about triflupromazine and pregnancy is most appropriate for counseling?

• It is completely safe and requires no discussion
• Use only if potential benefits justify potential fetal risks and under specialist guidance
• It always causes congenital malformations
• It enhances fetal growth and is recommended

Correct Answer: Use only if potential benefits justify potential fetal risks and under specialist guidance

Q50. When preparing an MCQ bank on triflupromazine, which topic should be emphasized for B.Pharm exam relevance?

• Mechanism of action, adverse effects, interactions, dosing and monitoring
• Only economic cost of the drug
• Irrelevant historical anecdotes
• Recipes for compounding unrelated mixtures

Correct Answer: Mechanism of action, adverse effects, interactions, dosing and monitoring

G S Sachin

I am a Registered Pharmacist under the Pharmacy Act, 1948, and the founder of PharmacyFreak.com. I hold a Bachelor of Pharmacy degree from Rungta College of Pharmaceutical Science and Research. With a strong academic foundation and practical knowledge, I am committed to providing accurate, easy-to-understand content to support pharmacy students and professionals. My aim is to make complex pharmaceutical concepts accessible and useful for real-world application.

Mail- Sachin@pharmacyfreak.com